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Cataract Surgery clinical trials

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NCT ID: NCT06425666 Not yet recruiting - Cataract Surgery Clinical Trials

Trial Comparing Cataract Surgery With Triple-DMEK in Patients With Cataract and Fuchs Endothelial Corneal Dystrophy

Start date: June 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate whether there is a difference in best spectacle corrected visual acuity (BSCVA) in patients treated with one of the following two surgeries: (1) cataract surgery with preservation of the diseased endothelial cells ("cataract surgery only experimental intervention, investigational therapy/ arm 1); (2) cataract surgery combined with removal of the diseased endothelial cells and the attached Descemet's membrane followed by transplantation of a healthy endothelial cell layer with attached Descemet's membrane ("triple-DMEK"(""cataract surgery only", control intervention comparator therapy/ arm 2)

NCT ID: NCT06257914 Not yet recruiting - Cataracts Clinical Trials

Aberrometry and Straylight Measurements as an Indication for Cataract Surgery

ASICS
Start date: February 2024
Phase:
Study type: Observational

Cataracts are a clouding of the lens of the eye. Cataract surgery replaces the cloudy lens with a clear artificial lens. It is one of the leading causes of low vision worldwide. Since cataracts are mostly age-related, the number of patients with cataracts is increasing sharply due to an ageing population. The indication for cataract surgery is currently based on the visual impairment experienced by the patient, a measurement of visual acuity and the ophthalmologist's assessment of the extent to which the clouding of the lens explains the patient's symptoms. It has been said that after cataract surgery, "the world opens up to you". However, about 10% of patients actually experience worse vision after surgery. This amounts to almost a whole month of potentially unnecessary surgery. It is therefore important to develop a more objective indicator for cataract surgery. Our study focuses on measuring the optical quality of the eye before and after cataract surgery. We also ask patients before and after cataract surgery how they themselves perceive the quality of their vision. We do this with different patient-reported outcomes. We investigate whether the objective measurement of the optical quality of the eye can predict which patients will be satisfied with the cataract surgery. With this, we aim to further improve patient care and prevent unnecessary surgery.

NCT ID: NCT06230029 Recruiting - Anxiety Clinical Trials

Music's Impact on Preoperative Anxiety: Heart Rate Variability Study During Cataract Surgery

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

The goal of this Randomized Controlled Trial is to evaluate heart rate variability (HRV)before and after listening to music in patients scheduled for cataract surgery under topical anesthesia, compared to patients who do not listen to music. Our hypothesis is that the anxious population with a low HRV benefits from an anxiolytic effect of music to increase HRV levels.

NCT ID: NCT06136780 Not yet recruiting - Cataract Surgery Clinical Trials

Impact of Free Reading Glasses on Work and Visual Function Following Cataract Surgery in Honduras

POWER
Start date: March 17, 2024
Phase: N/A
Study type: Interventional

Cataract surgery improves vision and is therefore assumed to improve a person's ability to work and function. Following cataract surgery, most patients do not need glasses to see clearly at distance, but they do require glasses to see clearly up close. If a patient is unable to acquire reading glasses after surgery due to either financial or logistical reasons, their ability to resume work and functioning may be compromised, diminishing the overall benefit to be gained from cataract surgery. Patients in the developing world may be affected disproportionately due to difficulty accessing care postoperatively. In this study, patients receiving cataract surgery at a clinic in Comayagua, Honduras will be randomized to either receive free reading glasses immediately after surgery or four months later. The primary outcome is the proportion of subjects who report that vision interferes with their ability to work. Secondary outcomes will include the number of hours worked each week at productive activities, income level, and visual functioning. The hypotheses are that the patients who receive free reading glasses immediately following surgery will be less likely to report that their vision interferes with their ability to work, they will work at productive activities a greater number of hours each week, their incomes will be higher, and their visual function scores will be higher.

NCT ID: NCT05980117 Not yet recruiting - Clinical trials for Cognitive Impairment

Remimazolam for Cataract Surgery

Start date: July 2024
Phase: Phase 4
Study type: Interventional

The goal of this study is to assess any post operative cognitive changes following benzodiazepine administration during cataract surgery. The investigators will compare effects of Midazolam vs. Remimazolam on cognition at the time of discharge from the post operative care unit and the next day following surgery. Cognitive changes will be assessed by administration of Montreal Cognitive Assessment (MoCA). Participants will: 1. Complete MoCA testing prior to surgery 2. Randomize in either Midazolam or study drug Remimazolam 3. Complete MoCA testing after surgery at the time of discharge in the post anesthesia care unit and the next day of surgery at the time of post operative surgical visit. 4. Complete Patient Satisfaction Survey at the time of discharge from the Post Anesthesia Care Unit (PACU)

NCT ID: NCT05925894 Completed - Cataract Surgery Clinical Trials

Efficacy Mydrane ® for Cataract Surgery in Patients With Concomitant Primary Open Angle Glaucoma.

MIGA
Start date: March 18, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to compare Mydrane ®, mydriatic eye drops and Mydriasert ® in terms of pupil site stability, surgical time, visual field and anterior chamber configuration modifications among primary open angle glaucoma (POAG) patients during cataract extraction surgery.

NCT ID: NCT05729477 Enrolling by invitation - Cataract Surgery Clinical Trials

A Prospective Multicenter Study To Assess The Clinical Outcomes Of Current Phacoemulsification Approach To Cataract Extraction Versus The Micor System Device

Start date: December 6, 2022
Phase: N/A
Study type: Interventional

The purpose of this research study is to evaluate the clinical outcomes of current phacoemulsification approaches to cataract extraction involving high-frequency thermogenic energy versus the use of the MICOR System device using low-energy segment removal with a micro-interventional irrigation/aspiration port to evacuate the lens in subjects undergoing routine cataract surgery.

NCT ID: NCT05692167 Recruiting - Anesthesia Clinical Trials

Dexmedetomidine in Topical Versus Peribulbar Anesthesia for Cataract Surgery

Start date: July 15, 2023
Phase: Phase 2
Study type: Interventional

The aim of this study is to compare efficacy of dexmedetomidine as an additive to topical versus peribulbar anesthesia for cataract surgery

NCT ID: NCT05690893 Completed - Cataract Surgery Clinical Trials

Crystalline Lens Tilt Evaluation Using Swept-source Optical Coherence Tomography

PhysTilt
Start date: February 1, 2023
Phase:
Study type: Observational

The goal of this retrospective study is to quantify the physiological lens tilt of the phakic eye. The main question it aims to answer is: -What influence does misalignment or tilting of IOLs have on visual quality? Preoperative biometry data are compared with anterior segement OCT data. Measurements were obtained using high-resolution swept-source optical coherence tomography. The influence of biometric measurements on tilt is analyzed.

NCT ID: NCT05331690 Recruiting - Cataract Surgery Clinical Trials

Cataract Surgery and Inflammation - the Role for Preoperative NSAIDs (Pre-CIN)

pre-CIN
Start date: November 25, 2022
Phase: Phase 4
Study type: Interventional

The pre-CIN trial is a randomized clinical three-arm trial comparing inflammation and cystoid macular edema for the medication regimens preoperative and postoperative topical NSAIDs to only postoperative topical NSAIDs to postoperative topical NSAIDs and steroids in patients undergoing cataract surgery.