Aqueous Urea Concentration May be Related to Cataract Development

Cataract Cortical Clinical Trial

Official title:

Aqueous Urea Concentration May be Related to Cataract Development

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03324295
• Other study ID #: IRB000078
• Status: Recruiting
• Phase: N/A
• First received: October 24, 2017
• Last updated: January 9, 2018
• Start date: January 2017
• Est. completion date: July 2018

Study information

• Verified date: October 2017
• Source: Assiut University
• Contact: Mohamed Gamal, Dr.
• Phone: 01004530716
• Email: mgsaleh05[@]yahoo.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

cataracts could be cured with eye drops. Some studies reported that in chronic renal failure, the occurrence of cataract is rare and the mechanism is unknown. The aim of this research is to describe correlation between urea concentration in the serum and aqueous humor and development of age related cataract.

Description:

The study was conducted in the departments of Ophthalmology and internal medicine,

Asyut University hospitals, Egypt. Three groups of subjects were included:

patients with age related cortical cataracts who are otherwise healthy (cases) and two control groups; first systemically healthy subjects with ocular problems other than cataract and a second control group of patients with impaired renal functions and are not on dialysis treatment and thus have elevated serum urea levels. Slit lamp examination was performed to evaluate crystalline lens for opacities. Measurement of serum urea was done for all study subjects. Aqueous humor urea concentration was done only for the group of patients who are planned to have intraocular surgery. For that purpose, 0.1 ml of aqueous humor will be aspirated at the start of routine intraocular surgery.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: July 2018
• Est. primary completion date: February 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• Senile Cortical cataract.

Exclusion Criteria:

• Senile Nuclear cataract.

• Congenital cataract

• Traumatic cataract

Related Conditions & MeSH terms

• Cataract
• Cataract Cortical

Intervention

Diagnostic Test:
• cortical cataract
Blood urea

Locations

Country	Name	City	State
Egypt	Hassan Lotfy	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood urea level	The relation between blood urea level and cataract	1 Day