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Clinical Trial Summary

Knee joint cartilage cells metabolize slowly, and it is difficult to repair themselves after injury. Any knee joint trauma or the progression of osteoarthritis may lead to the progression of cartilage or osteochondral defects. Compared with bone marrow mesenchymal stem cells (MSCs), peripheral blood MSCs have better chondrogenic differentiation ability. At the same time, the mobilization of peripheral blood MSCs and the advancement of extraction technology also make it feasible to treat osteochondral damage by using peripheral blood MSCs. The purpose of this study is to evaluate the therapeutic effect of surgical transplantation of autologous peripheral blood MSCs to repair knee joint Ⅳ-degree localized cartilage injury, and to explore a new treatment for osteochondral defects based on the foundation of the research group's previous research.


Clinical Trial Description

1. Explore the clinical efficacy of autologous peripheral blood mesenchymal stem cell transplantation in the treatment of osteochondral defects 2. Exploring the characteristics of cartilage regeneration in autologous peripheral blood mesenchymal stem cell transplantation ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04953572
Study type Interventional
Source Peking University Third Hospital
Contact Jia-kuo Yu, Prof.
Phone +86 13331031448
Email yujiakuo@126.com
Status Not yet recruiting
Phase Phase 1
Start date August 1, 2021
Completion date December 31, 2023

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