Treatment of Cartilage Defects With Peripheral Blood Stem Cells

Status Not yet recruiting

Clinical Trial Summary

Knee joint cartilage cells metabolize slowly, and it is difficult to repair themselves after injury. Any knee joint trauma or the progression of osteoarthritis may lead to the progression of cartilage or osteochondral defects. Compared with bone marrow mesenchymal stem cells (MSCs), peripheral blood MSCs have better chondrogenic differentiation ability. At the same time, the mobilization of peripheral blood MSCs and the advancement of extraction technology also make it feasible to treat osteochondral damage by using peripheral blood MSCs. The purpose of this study is to evaluate the therapeutic effect of surgical transplantation of autologous peripheral blood MSCs to repair knee joint Ⅳ-degree localized cartilage injury, and to explore a new treatment for osteochondral defects based on the foundation of the research group's previous research.

Clinical Trial Description

1. Explore the clinical efficacy of autologous peripheral blood mesenchymal stem cell transplantation in the treatment of osteochondral defects 2. Exploring the characteristics of cartilage regeneration in autologous peripheral blood mesenchymal stem cell transplantation ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04953572
Study type	Interventional
Source	Peking University Third Hospital
Contact	Jia-kuo Yu, Prof.
Phone	+86 13331031448
Email	yujiakuo@126.com
Status	Not yet recruiting
Phase	Phase 1
Start date	August 1, 2021
Completion date	December 31, 2023

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