Cartilage Injury Clinical Trial
Official title:
Effectiveness of Autologous Platelet-rich Plasma on Knee Cartilage Injury: a Randomized, Controlled, Open-label Clinical Trial
Verified date | January 2017 |
Source | Chinese PLA General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To analyze the effectiveness of intra-articular injection of autologous PRP on knee cartilage repair and evaluating functional recovery of the knee joint in knee cartilage injury patients.
Status | Completed |
Enrollment | 50 |
Est. completion date | May 2016 |
Est. primary completion date | May 2014 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 14 Years to 55 Years |
Eligibility |
Inclusion Criteria: - Knee cartilage injury - Having normal and stable joint motion but no deformity - Focal cartilage defects confirmed by magnetic resonance imaging (MRI), Outerbridge classification III/IV with a defect size < 10 cm2 graded as Outerbridge II at maximum - Focal articular cartilage injury in the knee - 14-55 years of age - Provision of signed informed consent to participate in the trial Exclusion Criteria: - Poor general condition - Blood diseases - Use of local hormone treatment within 3 months before the trial - Bleeding tendency - Drug addiction, including anesthetic, alcohol and poison - Inflammatory arthropathy, including specific and non-specific arthritis and severe osteoarthritis - Contagious viral infection - Metabolic diseases, such as gout and rheumatism - Pregnant or lactating, or planning to become pregnant within 1 year after the initial registration - Unable to cooperate with rehabilitation therapy because of psychological/mental disorders |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Chinese PLA General Hospital |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Lysholm score | To assess functional recovery of the knee joint. Lysholm score ranges from 0-100 with higher scores indicating better knee joint function. A score <70 indicates damage to the knee joint function. | at 3 months after final injection | |
Secondary | 2000 IKDC Subjective Knee Evaluation Form score | To used for assessing functional recovery of the knee joint. Higher scores indicate better recovery. | at 3 months after final injection | |
Secondary | Numerical rating scale score | To assess pain relief of the knee joint. The numerical rating scale score ranges from 0-10, with a score of 0 indicating no pain and 10 indicating intense pain. | changes of month 1, month 2 and month 3 after initial injection, and month 3 after final injection |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03479775 -
Muscle Function and Traumatic Knee Injury in Sports
|
||
Recruiting |
NCT03321812 -
Clinical Study of Decalcification Bone Scaffold for Cartilage Lesions of the Knee
|
N/A | |
Recruiting |
NCT06082531 -
Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis
|
N/A | |
Completed |
NCT06078072 -
Biomaterials and Mesenchymal Stem/Stromal Cells in the Treatment of Knee Articular Surface Lesions
|
||
Completed |
NCT04889443 -
Spontaneous Healing of ARticular Cartilage (SHARC)
|
||
Completed |
NCT04118023 -
7T MRI to Evaluate Cartilage Defects in the Knee
|
||
Active, not recruiting |
NCT01458782 -
ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee
|
N/A | |
Recruiting |
NCT03477942 -
Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
|
Phase 1 | |
Completed |
NCT01473199 -
BioPoly RS Knee Registry Study for Cartilage Defect Replacement
|
N/A | |
Recruiting |
NCT05124613 -
The Impact of Covid-19 on Patients Waiting for Knee Surgery
|
||
Recruiting |
NCT06344481 -
The Hyalex First-in-Human Study
|
Phase 1 | |
Completed |
NCT04739930 -
Autologous Bone Marrow Concentrate in Knee Osteochondral Allograft Transplantation
|
N/A | |
Active, not recruiting |
NCT03873545 -
Prospective Evaluation of ProChondrix CR for Repair of Articular Cartilage Defects on Femoral Condyle and Patella
|
||
Recruiting |
NCT05328674 -
Clinical and Comparative Evaluation of the Treatment Results of Arthroscopic Reconstruction of Cartilage Defects in the Knee Joint With the Use of Autogenous Cartilage Graft With PRP GF (Platelet-rich Plasma With Growth Factors)
|
N/A | |
Recruiting |
NCT04184687 -
The Treatment of Cartilaginous Lesions and Concomitant Anterior Cruciate Ligament Reconstruction
|
N/A | |
Terminated |
NCT04301258 -
ProChondrix® CR Articular Cartilage Restoration Evaluation (PACE) Registry
|
||
Completed |
NCT02696876 -
Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair
|
N/A | |
Completed |
NCT02637505 -
Norwegian Cartilage Project - Microfracture
|
N/A | |
Recruiting |
NCT04135950 -
Prospective Registry of Anterior Cruciate Ligament Reconstructions
|
||
Completed |
NCT01041001 -
Study to Compare Efficacy and Safety of Cartistem and Microfracture in Patients With Knee Articular Cartilage Injury
|
Phase 3 |