Carpal Tunnel Syndrome Clinical Trial
Official title:
Effects of Platelet-rich Plasma in the Surgery of Carpal Tunnel Syndrome: A Randomized
The Platelet-rich plasma (PRP) has been proved to be efficient in the non-surgical treatment
of carpal tunnel syndrome (CTS). Here we propose to assess the effectiveness of PRP as
co-adjuvant in surgical treatment of CTS by open carpal tunnel release.
Design: Randomized Controlled Trial. Setting: Local Hospital.
Carpal tunnel syndrome (CTS) is a common disorder with an estimated annual incidence of
125-542 in adults, and an estimated prevalence of 1 to 5 percent in the general population.
CTS is the most frequent compressive focal mononeuropathy and causes pain, paresthesia and
weakness of the median nerve distribution in patients.
The treatment of the CTS includes both, conservative and surgical treatment depending on the
severity of the symptoms.
Platelet-rich plasma (PRP) has been proved to be efficient in the non-surgical treatment of
CTS, however its potential used as co-adjuvant in surgical treatment has not been assessed.
We propose a randomized clinical trial in patients in which the surgical treatment is
indicated. Participants in the intervention group receive a PRP injection, and in the control
group a platelet-poor plasma injection after open carpal tunnel release. The evaluation is
performed pretreatment as well as on the 6st week after treatment. Outcome measures include:
hand grip strength (primary outcome), pain, sympton severity and functional status.
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