The Volume Effect of Nerve Hydrodissection for Carpal Tunnel Syndrome

Status Completed

Clinical Trial Summary

Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel. Although many conservative managements of CTS, the effectiveness of these methods is insignificant or only persist for a short duration. The technique of nerve hydrodissection is now commonly used for peeling the nerve from surrounding soft tissue, which may help allow the impulse to pass, and rescue the nerve with ischemic damage. However, the exact effect and interval of hydrodissection are unknown because of the lack of well-designed studies Hence, investigators design a randomized, double- blind, controlled trail to assess the therapeutic effect of ultrasound-guided nerve hydrodissection in patients with CTS.

Clinical Trial Description

After obtaining written informed consent, patients clinically diagnosed with mild-to-moderate CTS were inclused and randomized into three groups. Group A, patients received one-session of ultrasoung-guided nerve hydrodissection with 10cc normal saline; Group B, patients received one-session of ultrasoung-guided nerve hydrodissection with 5cc normal saline; The injection syringe was covered to obscure the nature of its contents and patients were asked to turn their head away so that they would not see the procedure. As a result, patients were blinded to the treatment condition. The primary outcome is Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) and secondary outcomes include visual analog scale (VAS), cross-sectional area (CSA) of the median nerve, sensory nerve conduction velocity of the median nerve, and global assessment of treatment. The evaluations were performed pretreatment as well as on the 2nd week, 1st, 3rd and 6th month after injecton. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03381521
Study type	Interventional
Source	Tri-Service General Hospital
Contact
Status	Completed
Phase	N/A
Start date	August 1, 2018
Completion date	December 31, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05067205` - Minimal Invasive Carpal Tunnel Release With the Novel Device	N/A
Completed	`NCT03184688` - Platelet Rich Plasma for Carpal Tunnel Syndrome	N/A
Completed	`NCT03582735` - Preoperative Neuromobilization Exercises for Individuals With Carpal Tunnel Syndrome	N/A
Completed	`NCT05490420` - Effects of Upper Extremity Manual Lymphatic Drainage on Symptom Severity, Hand Functions, Electrophysiological and Ultrasonographic Measurements in Carpal Tunnel Syndrome	N/A
Recruiting	`NCT05970692` - Cross-Cultural Adaptation and Psychometric Validation of the Turkish Version of Atroshi-Lyrén 6-item Symptoms Scale
Completed	`NCT04043780` - Clinical Validation of a Decompression Prototype Splint for Patients With Carpal Tunel Syndrome	N/A
Completed	`NCT03880812` - Cost Information on Carpal Tunnel Syndrome Treatment Decisions	N/A
Completed	`NCT06464809` - Treatment Intervention of Patients With Carpal Tunnel Syndrome (CTS)	N/A
Recruiting	`NCT05503719` - An Absorbable Suture Versus a Non-absorbable Suture in Carpal Tunnel Release, a Randomized Controlled Trial	N/A
Recruiting	`NCT05328180` - aDjunct bicarbonatE in Local anaesthesIa for CarpAl Tunnel rElease (DELICATE)	N/A
Recruiting	`NCT05372393` - Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block	N/A
Recruiting	`NCT05466162` - Soft Tissue Massage Along With Mobilization Technique on Symptoms and Functional Status of Carpal Tunnel Syndrome	N/A
Completed	`NCT04060875` - Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain
Not yet recruiting	`NCT06294821` - 4AP to Delay Carpal Tunnel Release (CTR)	Phase 2/Phase 3
Not yet recruiting	`NCT04328805` - Pain Reduction and Changes in Upper Limb Function Produced by an Ibuprofen Treatment in Carpal Tunnel Syndrome.	Phase 4
Terminated	`NCT02791529` - Scalpel Versus Electrocautery for Surgical Skin Incision in Open Carpal Tunnel Release	Phase 1
Completed	`NCT02141035` - Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome	Phase 2/Phase 3
Completed	`NCT01887145` - Comparison of Long-term Outcomes Following Endoscopic or Open Surgery for Carpal Tunnel Syndrome	N/A
Recruiting	`NCT01897272` - Post-Operative Splinting After Short-Incision Carpal Tunnel Release: a Prospective Study	N/A
Completed	`NCT01394822` - Neuromuscular Ultrasound for Focal Neuropathies	N/A