Platelet Rich Plasma for Carpal Tunnel Syndrome

Status Completed

Clinical Trial Summary

Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel. Although many conservative managements of CTS, the effectiveness of these methods is insignificant or only persist for a short duration. The platelet rich plasma (PRP) is a new and potential treatment for patients with kinds of musculoskeletal disorders and recent reports showed being beneficial for peripheral neuropathy in animal studies. Since 2014, four small clinical trials showed the positive effect of PRP in peripheral neuropathy. Among these studies, two small trials showed beneficial effect of PRP for patients with mild CTS. However, the definite clinical effect of PRP for peripheral neuropathy from currently published studies is unclarified because these studies enrolled a few patients and lacked long-term follow-up (no more than 6 months follow-up).

Clinical Trial Description

After obtaining written informed consent, patients of clinically diagnosed with bilateral CTS were randomized into intervention and control side. Intervention group received one-dose ultrasound-guided PRP injection and control group received one-dose ultrasound-guided normal saline injection. No additional treatment after injection through the study period. The primary outcome is Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) and secondary outcomes include visual analog scale (VAS), cross-sectional area (CSA) of the median nerve, sensory nerve conduction velocity of the median nerve, and finger pinch strength. The evaluation was performed pretreatment as well as on the 2nd week, 1st, 3rd, 6th month and one year after the treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03184688
Study type	Interventional
Source	Tri-Service General Hospital
Contact
Status	Completed
Phase	N/A
Start date	September 8, 2017
Completion date	October 30, 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05067205` - Minimal Invasive Carpal Tunnel Release With the Novel Device	N/A
Completed	`NCT03582735` - Preoperative Neuromobilization Exercises for Individuals With Carpal Tunnel Syndrome	N/A
Completed	`NCT05490420` - Effects of Upper Extremity Manual Lymphatic Drainage on Symptom Severity, Hand Functions, Electrophysiological and Ultrasonographic Measurements in Carpal Tunnel Syndrome	N/A
Recruiting	`NCT05970692` - Cross-Cultural Adaptation and Psychometric Validation of the Turkish Version of Atroshi-Lyrén 6-item Symptoms Scale
Completed	`NCT04043780` - Clinical Validation of a Decompression Prototype Splint for Patients With Carpal Tunel Syndrome	N/A
Completed	`NCT03880812` - Cost Information on Carpal Tunnel Syndrome Treatment Decisions	N/A
Completed	`NCT06464809` - Treatment Intervention of Patients With Carpal Tunnel Syndrome (CTS)	N/A
Recruiting	`NCT05372393` - Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block	N/A
Recruiting	`NCT05503719` - An Absorbable Suture Versus a Non-absorbable Suture in Carpal Tunnel Release, a Randomized Controlled Trial	N/A
Recruiting	`NCT05328180` - aDjunct bicarbonatE in Local anaesthesIa for CarpAl Tunnel rElease (DELICATE)	N/A
Recruiting	`NCT05466162` - Soft Tissue Massage Along With Mobilization Technique on Symptoms and Functional Status of Carpal Tunnel Syndrome	N/A
Completed	`NCT04060875` - Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain
Not yet recruiting	`NCT06294821` - 4AP to Delay Carpal Tunnel Release (CTR)	Phase 2/Phase 3
Not yet recruiting	`NCT04328805` - Pain Reduction and Changes in Upper Limb Function Produced by an Ibuprofen Treatment in Carpal Tunnel Syndrome.	Phase 4
Terminated	`NCT02791529` - Scalpel Versus Electrocautery for Surgical Skin Incision in Open Carpal Tunnel Release	Phase 1
Completed	`NCT02141035` - Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome	Phase 2/Phase 3
Completed	`NCT01887145` - Comparison of Long-term Outcomes Following Endoscopic or Open Surgery for Carpal Tunnel Syndrome	N/A
Recruiting	`NCT01897272` - Post-Operative Splinting After Short-Incision Carpal Tunnel Release: a Prospective Study	N/A
Completed	`NCT01394822` - Neuromuscular Ultrasound for Focal Neuropathies	N/A
Enrolling by invitation	`NCT01017471` - Carpal Tunnel Syndrome Release Using PSU Retractor	Phase 3