Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid

Status Not yet recruiting

Clinical Trial Summary

This study was a single-center, exploratory, randomized controlled trial. First, the effects of ephedrine, phenylephrine, or norepinephrine on cerebral blood flow hemodynamics in CEA patients were evaluated using DSC-MRI to investigate the specific mechanisms of the three vasopressors on cerebral blood flow and oxygen metabolism in brain tissues.

Clinical Trial Description

Carotid endarterectomy is a procedure used to remove plaque from the common and internal carotid arteries and improve cerebral perfusion. Clinical studies have demonstrated the effectiveness of this procedure in both symptomatic and asymptomatic patients. intraoperative circulatory management challenges in CEA include the following: ① The incidence of preoperative combined coronary artery disease, hypertension and diabetes mellitus is relatively high in patients undergoing carotid endarterectomy, and there is a pathological basis for systemic vascular injury, increasing the risk of perioperative cardiovascular and cerebrovascular complications, such as myocardial ischemia and stroke. ② During the CEA procedure, the common carotid artery, internal carotid artery and external carotid artery and the superior thyroid artery need to be blocked respectively, the source of blood supply to the cerebral hemisphere on the operated side is reduced and depends only on the Willis circle supply. ③ Carotid sinus pressure receptor pull stimulation causes circulatory fluctuations. During CEA, a relatively high arterial pressure is required to provide adequate cerebral perfusion. However, achieving this target blood pressure level intraoperatively can be challenging due to given conditions, the presence of induction drugs and anesthetics. Therefore, it is particularly important to maintain cerebral hemodynamic stability and ensure tissue perfusion with intraoperative use of vasopressers. The purpose of this study was to evaluate the effects of ephedrine, phenylephrine, or norepinephrine on cerebral blood flow hemodynamic in CEA patients using DSC-MRI to investigate the specific mechanisms of the three boosting agents on cerebral blood flow and oxygen metabolism in brain tissues. ;

Study Design

Related Conditions & MeSH terms

Carotid Endarterectomy

Clinical Trial Details

NCT number	NCT05414877
Study type	Interventional
Source	Beijing Tiantan Hospital
Contact	Ruquan Han, M.D.,PhD
Phone	01059976660
Email	ruquan.han@gmail.com
Status	Not yet recruiting
Phase	N/A
Start date	September 30, 2023
Completion date	December 31, 2024

View Details

See also
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Completed	`NCT03596229` - Major Adverse Cardiac Events After Carotid Endarterectomy
Recruiting	`NCT05665881` - Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (TCD Part)	N/A
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Not yet recruiting	`NCT06406842` - Association Between Local Cerebral Oxygenation Monitoring and Postoperative Stroke in Carotid Endarterectomy	N/A
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Terminated	`NCT02102386` - Monitoring Brain Perfusion and Cerebral Oximetry in Carotid Endarterectomy Surgeries	N/A
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Recruiting	`NCT06222983` - Efficacy and Prognosis of Surgical Intervention in Patients With Carotid Artery Stenosis
Completed	`NCT04960488` - Multidisciplinary CAE and CABG Surgery to Optimize the Management of High-risk Patients During the Perioperative Period	N/A
Completed	`NCT01404819` - Evaluation of Brain Damage Resulting From Carotid Endarterectomy With Xenon Anesthesia	N/A
Recruiting	`NCT05267782` - Correlation Between New O3 Regional Oximetry, Electroencephalography and the Somatosensory Evoked Potential in Carotid Endarterectomy Surgery
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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part)

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms