Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT05414877 |
| Other study ID # |
wxy20220526 |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
September 30, 2023 |
| Est. completion date |
December 31, 2024 |
Study information
| Verified date |
August 2023 |
| Source |
Beijing Tiantan Hospital |
| Contact |
Ruquan Han, M.D.,PhD |
| Phone |
01059976660 |
| Email |
ruquan.han[@]gmail.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
This study was a single-center, exploratory, randomized controlled trial. First, the effects
of ephedrine, phenylephrine, or norepinephrine on cerebral blood flow hemodynamics in CEA
patients were evaluated using DSC-MRI to investigate the specific mechanisms of the three
vasopressors on cerebral blood flow and oxygen metabolism in brain tissues.
Description:
Carotid endarterectomy is a procedure used to remove plaque from the common and internal
carotid arteries and improve cerebral perfusion. Clinical studies have demonstrated the
effectiveness of this procedure in both symptomatic and asymptomatic patients. intraoperative
circulatory management challenges in CEA include the following: ① The incidence of
preoperative combined coronary artery disease, hypertension and diabetes mellitus is
relatively high in patients undergoing carotid endarterectomy, and there is a pathological
basis for systemic vascular injury, increasing the risk of perioperative cardiovascular and
cerebrovascular complications, such as myocardial ischemia and stroke. ② During the CEA
procedure, the common carotid artery, internal carotid artery and external carotid artery and
the superior thyroid artery need to be blocked respectively, the source of blood supply to
the cerebral hemisphere on the operated side is reduced and depends only on the Willis circle
supply. ③ Carotid sinus pressure receptor pull stimulation causes circulatory fluctuations.
During CEA, a relatively high arterial pressure is required to provide adequate cerebral
perfusion. However, achieving this target blood pressure level intraoperatively can be
challenging due to given conditions, the presence of induction drugs and anesthetics.
Therefore, it is particularly important to maintain cerebral hemodynamic stability and ensure
tissue perfusion with intraoperative use of vasopressers.
The purpose of this study was to evaluate the effects of ephedrine, phenylephrine, or
norepinephrine on cerebral blood flow hemodynamic in CEA patients using DSC-MRI to
investigate the specific mechanisms of the three boosting agents on cerebral blood flow and
oxygen metabolism in brain tissues.
