Carotid Atherosclerosis Clinical Trial
Official title:
The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution.
The goal of this clinical trail is to compare the differences in carotid plaque Treg cells' gene signature for activation, proliferation, and suppressive function using scRNA-seq in patients treated with IL-2 compared to control.
Up till now our Lab has looked at Tregs and immune cells in the blood. The question remains whether low dose IL-2 can have the desired effect on Tregs in atherosclerotic plaques where they could alter the pathophysiology and potentially clinical outcomes for patients. Up until recently, the cellular composition and cell-specific expression patterns of human atherosclerotic plaques remained elusive. However, recent breakthroughs studies using scRNA-seq, CITE-seq, and single-cell ATAC-seq on human carotid plaques have offered important insight into plaque composition, cell heterogeneity, and cell-cell interactions giving new perspectives on mechanisms of disease. The next logical stage is to use this new insight and powerful biological tool to assist in drug development for patients. Therefore, the aims of the study are: 1. To assess if low dose IL-2, given systemically to patients at our proposed dose, can alter Tregs in atherosclerotic plaques (the disease tissue) to exhibit a proliferating, activated, and immunosuppressive phenotype 2. To assess if modulating plaque Tregs can cause a shift in the plaque immune landscape to a less inflammatory phenotype 3. To study the relationship between plaque and circulating immune cells after systemic immune modulation ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03248401 -
Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes
|
Phase 4 | |
Withdrawn |
NCT03630835 -
99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques
|
Phase 2/Phase 3 | |
Completed |
NCT02722720 -
Carotid Arteries Stenting Complications: Transradial Approach Versus Transfemoral
|
N/A | |
Completed |
NCT01893489 -
Visualization of Carotid Atherosclerosis by 68Ga-MSA
|
Phase 1 | |
Withdrawn |
NCT00861159 -
RLIP76 in Human Serum in Adults With Rheumatologic Diseases
|
N/A | |
Recruiting |
NCT01743404 -
Study of Anti-atherosclerotic Activity of Inflaminat in Asymptomatic Participants With Subclinical Atherosclerosis
|
Phase 2 | |
Completed |
NCT00636766 -
Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque
|
N/A | |
Recruiting |
NCT06166121 -
Study on Hyperlipidemia Combined With Carotid Atherosclerosis With ShenJu Granules
|
N/A | |
Withdrawn |
NCT03382249 -
Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With Carotid Atherosclerotic Plaques
|
Phase 1/Phase 2 | |
Recruiting |
NCT04679727 -
The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study
|
||
Withdrawn |
NCT02995642 -
Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation
|
Phase 2 | |
Suspended |
NCT01000181 -
Imaging 61CuATSM Uptake in Atherosclerotic Plaque Using PET-CT
|
N/A | |
Completed |
NCT00001368 -
Potential Risk Factors for Stroke
|
Phase 1 | |
Recruiting |
NCT04537403 -
PET Detection of CCR2 in Human Atherosclerosis
|
Phase 1 | |
Recruiting |
NCT05800821 -
Prediction of Cerebral Hyperperfusion Syndrome After Carotid Revascularization Using Deep Learning
|
||
Completed |
NCT00147797 -
Influence of Pravastatin on Carotid Artery Structure and Function in HIV-infected Patients Under Antiretroviral Therapy
|
N/A | |
Completed |
NCT00147251 -
Stop Atherosclerosis in Native Diabetics Study
|
Phase 4 | |
Completed |
NCT00180518 -
ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial"
|
Phase 2/Phase 3 | |
Completed |
NCT05230576 -
Intelligent Detection of Carotid Plaque and Its Stability Based on Deep Learning Dynamic Ultrasound Scanning
|
||
Terminated |
NCT03764306 -
New Ischemic Cerebral Lesions After Endarterectomy vs. Stenting for the Treatment of Symptomatic Carotid Stenosis
|
N/A |