Carotid Plaque Regression With Statin Treatment Assessed by High Field Magnetic Resonance Imaging (MRI)

Carotid Atherosclerosis Clinical Trial

Official title:

Short Term Carotid Plaque Regression in Patients With Atherosclerotic Disease Taking Statins Assessed by High Field MRI

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT00388843
• Other study ID #: PRO00002285
• Status: Withdrawn
• Phase: Phase 4
• First received: October 16, 2006
• Last updated: August 21, 2015
• Start date: August 2006
• Est. completion date: February 2009

Study information

• Verified date: August 2015
• Source: Medical College of Wisconsin
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

The purpose of the study is to determine if short term (6 months) treatment with statins to lower low-density lipoprotein (LDL) in vascular disease patients with carotid plaque will be associated with a measurable reduction in carotid plaque volume using 3 Tesla MRI. The researchers will correlate the change in plaque volume to degree of LDL lowering. The researchers will also study if brief treatment will lead to change in plaque composition. The researchers will compare the change in plaque volume measured by 3T MRI with plaque burden measured by ultrasound.

Description:

Atherosclerotic vascular disease is the leading cause of death in the United States. Atherosclerosis develops with increasing plaque burden and eccentric arterial wall expansion or remodeling, later leading to luminal obstruction. More than 90% of patients with CAD have carotid plaques. Statins have been shown to cause plaque regression in the carotid and coronary arteries. However, there is ongoing controversy about how low the target LDL should be in atherosclerotic patients. The benefits of aggressive LDL lowering with higher statin doses are counterbalanced by the potential for liver and muscle toxicity. High field (3 Tesla) MRI is a promising new modality for measuring plaque volume with high spatial resolution. It is not clear whether increasing statin dose will lead to plaque volume reduction in the short-term (6 months) that can be measured by this new modality.

The primary aim of the study is to determine if LDL lowering using statins in vascular disease patients with carotid plaque will be associated with measurable reduction in carotid plaque volume in the short term (6 months) using 3T MRI.

The four secondary aims of the study are as follows:

To compare the short term carotid plaque volume change using high field MRI in vascular disease patients whose statin dose was increased (dose increased) versus those whose statin dose was maintained (dose maintained).

To determine if increasing statin dose in patients with carotid plaque will lead to measurable change in carotid plaque composition in the short term (6 months) using 3T MRI.

To compare the carotid plaque volume change using 3T MRI with change in plaque burden score using carotid ultrasound .

To determine the relationship between change in plaque volume with change in lipid levels (total cholesterol, LDL, HDL) and change in inflammatory markers (cytokines, high sensitivity CRP).

The study is significant because it will provide insight into optimal statin treatment for atherosclerotic disease. It will also test a new modality for measurement of plaque burden. A reliable and sensitive test with high spatial resolution that accurately measures change in plaque volume will be helpful in assessing response to treatment and as a tool for future clinical trials in assessing efficacy of new treatment modalities that may reduce the need for expensive, long term studies that rely on clinical events for outcome measurement.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: February 2009
• Est. primary completion date: February 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 21 Years and older

Eligibility

Inclusion criteria:

• Adult (> 21 years old) patients.

• Diagnosed with coronary artery disease or suspected cerebrovascular accident.

• For dose increased subjects, patients whose statin dose or LDL lowering therapy is doubled or increased from standard dose to high dose (see table).

• For dose maintained subjects, patients whose statin dose or LDL lowering therapy is maintained at standard dose (see table).

• Standard Dose (reported LDL? < 40% from literature)

• Drug Daily Dose/s: (md/day)

• atorvastatin 10

• simvastatin 5, 10, 20

• pravastatin 10, 20, 40, 80

• fluvastatin 20, 40, 80

• lovastatin 10, 20, 40

• High Dose (reported LDL? > 40% from literature)

• Drug Daily Dose/s (mg/day)

• atorvastatin 40, 80

• simvastatin 40, 80

• lovastatin 80

• rosuvastatin 5, 10, 20, 40

• Addition of non-statin lipid transfer (tx) (e.g., ezetimibe, fibrate, niacin) to standard statin dose

Exclusion criteria:

• severe claustrophobia causing inability to undergo MRI implanted ferromagnetic materials (pacemakers, defibrillators, TENS units, aneurysm clips, etc.) that are not suitable for MRI in the clinical setting

• patients anticipated to undergo carotid stenting or surgery in next 6 months

• patients unable to lie flat for 1 hour

• patients requiring supplemental oxygen

• pregnant women

• patients who could not be followed up for 6 months

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Atherosclerosis
• Carotid Artery Diseases
• Carotid Atherosclerosis

Locations

Country	Name	City	State
United States	Medical College of Wisconsin/Froedtert Memorial and Lutheran Hospital	Milwaukee	Wisconsin

Sponsors (1)

Lead Sponsor	Collaborator
Medical College of Wisconsin

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in carotid artery plaque volume assessed by carotid MRI at 6 months		6 months	No
Secondary	Change in carotid intima media thickness on ultrasound at 6 months		6 months	No
Secondary	Change in plaque composition by carotid MRI at 6 months		6 months	No
Secondary	Change in inflammatory markers at 6 months		6 months	No
Secondary	Change in regional wall shear stress in the carotid artery		6 months	No

External Links

•   Medical College of Wisconsin site