A Perspective, Self-control Study on the Progression of Carotid Plaques in Anti-PD-1 mAb Treated Tumor Patients by Artery Ultrasound Follow-up

Carotid Artery Plaque Clinical Trial

Official title: A Perspective, Self-control Study on the Progression of Carotid Plaques in Anti-PD-1 mAb Treated Tumor Patients by Artery Ultrasound Follow-up

Status Recruiting

Clinical Trial Summary

A Perspective, Self-control Study on the Progression of Carotid Plaques in Anti-PD-1 mAb Treated Tumor Patients by Artery Ultrasound Follow-up

Clinical Trial Description

This is a perspective, self-controlled cohort study. This study aims to evaluate the effectiveness of anti-PD-1 mAbs (PD-1 immune checkpoint blockades) on atherosclerotic carotid plaques in those anti-PD-1 mAbs treated patients. The method for quantification and evaluation of atherosclerotic plaques are based on the: ① The mean intima-media thickness of the common carotid artery (Mean CCA thickness); ② The maximum intima-media thickness of the internal carotid artery (maximum ICA thickness); ③ Carotid plaque burden: by calculation of the plaque area of atherosclerotic plaques on the long axis direction of artery on the ultrasound images. By comparing the above-mentioned parameters at the same location of carotid artery in each patient when initiate the first-dose of anti-PD-1 mAbs therapy and 3 months post anti-PD-1 mAbs therapy. It is designed to assess the effectiveness of anti-PD-1 mAbs on the progression of carotid plaques. ;

Related Conditions & MeSH terms

• Carotid Artery Plaque
• Carotid Stenosis
• Immune Checkpoint Inhibitors
• Intimal Medial Thickness of Internal Carotid Artery
• Plaque, Atherosclerotic

• NCT number: NCT05123287
• Study type: Observational [Patient Registry]
• Source: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Contact: Jianan Wang, MD, PhD
• Phone: +86 0571 87784808
• Email: wangjianan111@zju.edu.cn
• Status: Recruiting
• Start date: October 8, 2021
• Completion date: December 1, 2022