Type 1 Diabetes Clinical Trial
Carnosine, a naturally-occurring dipeptide (β-alanyl-L-histidine) first described in 1900 by
Gulewitsch and Amiradzibi, is found predominantly in post-mitotic tissues (e.g. brain and
innervated muscle) of vertebrates . Carnosine is claimed to decrease oxygen free-radical
mediated damage to cellular macromolecules either by chelating divalent cations or
scavenging hydroxy radicals with its imidazole moiety. Free-radical damage is not the only
process to affect the structure of proteins and nucleic acids.
To the best of our knowledge, no previous study assessed the role of carnosine in diabetes
associated complications in particular diabetic nephropathy and there is insufficient
evidence to recommend its supplementation in those patients. Therefore, this study was
undertaken to investigate the role of carnosine as an adjuvant therapy for diabetic
nephropathy in children and adolescents with type 1 diabetes and assess its relation to
microalbuminuria, tubulointerstitial damage marker, glycemic control and oxidative stress.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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