Caries Clinical Trial
Official title:
Dental Plaque Microbiota in Caries-free and Caries-active Arab Children
Dental caries is a polymicrobial infection originally thought to be caused by Streptococcus mutans and Lactobacilli. However, unprecedented developments in modern molecular techniques have demonstrated that several microbial species are associated with the disease in addition to streptococci and lactobacilli. Dental caries initiation and progression is a dynamic process in which demineralization of the tooth structure, as a result of acid production from acidogenic bacteria (due to carbohydrate metabolism) is being counteracted by the remineralization of the tooth surface by strong alkali production by certain bacteria in the dental biofilm. The aim of the present study is to identify the different microbiota in the oral biofilm using new laboratory techniques as well as the levels of salivary proteins in caries-free compared with caries active Arab children.
The objective of this study will be to investigate the dental plaque's microbial diversity
using Human Oral Microbe Identification using Next Generation Sequencing (HOMINGS) technology
in the mixed dentition as well as the levels of salivary proteins in caries-free compared
with caries active Arab children. The study protocol was approved by the Health Science
Center Ethical Committee at Kuwait University.
One hundred 6-9 year-old children with caries active and caries-free status will be recruited
from randomly selected public schools in Kuwait. After DNA purification from supragingival
plaque samples, HOMINGS will be performed. To get an insight into the host factors involved
in this complex interplay between the host and the bacteria, stimulated saliva from the study
subjects will be analyzed by proteomics. For children in both groups supragingival plaque
samples will be collected from the buccal and lingual surfaces of all teeth. After preparing
the samples, the aliquots of purified DNA samples will be shipped to The Forsyth Institute
for Human Oral Microbe Identification using Next Generation Sequencing (HOMINGS) protocol.
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