Cardiovascular Clinical Trial
Official title:
Exercise and Cardiovascular Control During Upright Tilt in Older Adults With Type 2 Diabetes
Verified date | April 2017 |
Source | University of British Columbia |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Older persons with diabetes have a harder time maintaining blood pressure when standing up. When blood pressure drops when standing up, fainting may occur. This study will see how regular exercise can improve the ability of the body to keep blood pressure up when standing. We want to see how this improvement varies with different types of exercise. The types of exercise that we will be studying are aerobic (running or cycling on a stationary bike) and strength training (weight lifting).
Status | Completed |
Enrollment | 64 |
Est. completion date | April 2012 |
Est. primary completion date | April 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 65 Years and older |
Eligibility |
Inclusion Criteria: - Type 2 diabetes for at least 5 years treated with diet alone or oral agents Nonsmoker for at least 5 years Subjects must be sedentary BMI between 24 and 35 All subjects will have a fasting glucose of <12 mM and a hemoglobin A1c < 8.5% All subjects must have developed hypertension CDA guidelines (systolic greater than 130 or diastolic greater than 80) Exclusion Criteria: - Abnormalities on complete blood count, electrolytes or creatinine, on resting ECG, treadmill exercise stress test Significant pulmonary, exercise-limiting orthopedic or neurological impairment Evidence of valvular disease, exercise-induced syncope, angina, arrhythmias or peripheral vascular disease Poor blood pressure control as defined as systolic blood pressure greater than or equal to 160 mm Hg or diastolic blood pressure greater than or equal to 90 mm Hg Total cholesterol/HDL cholesterol greater than or equal to 5.0 or LDL cholesterol greater than or equal to 4.21 mmol/L Peripheral neuropathy severe enough to cause discomfort (for safety reasons) Significant orthostatic hypotension defined as a drop in systolic blood pressure greater than 30 mmHg during one of five consecutive arterial blood pressure readings immediately after changing position from lying to standing for safety. Overt diabetic nephropathy excluding subjects with a urine albumin to creatinine ratio of greater than 2.0 in men or 2.8 in women Diabetic retinopathy |
Country | Name | City | State |
---|---|---|---|
Canada | Vancouver General Hospital Research Pavilion | Vancouver | British Columbia |
Lead Sponsor | Collaborator |
---|---|
University of British Columbia | Canadian Institutes of Health Research (CIHR) |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pulse wave velocity (central and peripheral) | Unspecified | ||
Primary | Drop in middle cerebral artery velocity with upright tilting | Unspecified | ||
Primary | Drop in blood pressure with upright tilt | Unspecified | ||
Primary | Arterial baroreflex sensitivity | Unspecified | ||
Primary | Time and frequency domain measures of heart rate variability | Unspecified | ||
Secondary | Fasting blood glucose, HgbA1C | Unspecified | ||
Secondary | VO2max | Unspecified | ||
Secondary | Dynamometry measures of muscle strength | Unspecified | ||
Secondary | Resting and maximal heart rate | Unspecified | ||
Secondary | Waist to hip ratio, BMI | Unspecified | ||
Secondary | Lean body mass/% fat | Unspecified | ||
Secondary | Catecholamines | Unspecified | ||
Secondary | Increase in Gosling's pulsatility index | Unspecified | ||
Secondary | Linear transfer-function analysis of cerebral autoregulation during upright tilt | Unspecified |
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