Clinical Trials Logo
  1. Home
  2. Cardiovascular Risk Factor
  3. NCT04329624

Effect Levosimendan Administration on Postoperative NT-proBNP in Cardiac Risk Patients — IMPROVE  

Cardiovascular Risk Factor Clinical Trial

Official title:
The Effect of Perioperative LevosIMendan Administration on Postoperative N-terminal pRo Brain Natriuretic Peptide Concentration in Patients With Increased cardiOVascular Risk Factors Undergoing Noncardiac surgEry - A Double-blinded Randomized Clinical Trial

Clinical Trial Summary

This is a prospective randomised trial investigating the effect of a preemptive administration of levosimendan on postoperative cardiac NT-proBNP concentrations.

Clinical Trial Description

Major cardiovascular complications occur in about 3 % of all patients undergoing noncardiac surgery and are even higher in patients with increased preoperative risk factors. N-terminal pro brain natriuretic peptide (NT-proBNP) increases in over two third of patients undergoing surgery and is a strong predictor for perioperative myocardial complications. Levosimendan is a positive inotropic Ca2+ sensitizer and significantly reduces postoperative BNP concentration in cardiac surgery. The evidence in the non-cardiac surgery setting, however, is weak. Therefore, we will test our primary hypothesis that the perioperative administration of levosimendan significantly will reduce postoperative NT-proBNP concentrations in patients undergoing moderate- to high-risk non-cardiac surgery. We will also test the secondary hypotheses that levosimendan will reduce postoperative maximum troponin T (maxTnT) concentration, the incidence of myocardial injury after noncardiac surgery (MINS), myocardial infarction and death within 30 days and one year after surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04329624
Study type Interventional
Source Medical University of Vienna
Contact
Status Active, not recruiting
Phase Phase 3
Start date October 10, 2020
Completion date November 2, 2024
View Details
See also
  Status Clinical Trial Phase
Completed NCT03644524 - Heat Therapy and Cardiometabolic Health in Obese Women N/A
Enrolling by invitation NCT04253054 - Chinese Multi-provincial Cohort Study-Beijing Project
Completed NCT03680638 - The Effect of Antioxidants on Skin Blood Flow During Local Heating Phase 1
Recruiting NCT04481503 - Transthoracic Echocardiography of Ventricular Function of Parturients in Labor
Terminated NCT04088240 - Effects of Omega-3 Docosapentaenoic Acid on Lipids and Other Risk Factors for Cardiovascular Disease N/A
Completed NCT03410342 - The Effects of Types of Fruits and Vegetables on Vascular Function N/A
Completed NCT03170752 - Implementing and Testing a Cardiovascular Assessment Screening Program (CASP) N/A
Recruiting NCT04231838 - Metabolic Syndrome in Diabetic Smokers Using Cigarettes & Combustion-Free Nicotine Delivery Systems N/A
Active, not recruiting NCT03902431 - Translating the ABCS Into HIV Care N/A
Terminated NCT03517111 - The Impact of a Parenting Intervention on Latino Youth Health Behaviors N/A
Completed NCT04562467 - The Use of Icosapent Ethyl on Vascular Progenitor Cells in Individuals With Elevated Cardiovascular Risk Phase 4
Completed NCT03429920 - Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors N/A
Completed NCT04551872 - RESILIENCE: Personalizing Cardiovascular Health N/A
Enrolling by invitation NCT03314818 - Natural History of Carotid Plaque as Determined by 3D Ultrasound N/A
Completed NCT03060811 - Mediterranean Diet, Trimethylamine N-oxide (TMAO) and Anti-oxidants in Healthy Adults N/A
Completed NCT04279704 - Overcoming Obstacles in Epigenetic Analysis of Human Twins
Completed NCT01050205 - The Healthy Lifestyle Project N/A
Completed NCT03570840 - Pediatric Metabolic Syndrome Study
Completed NCT03039023 - Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans N/A
Completed NCT03646175 - Choline Supplementation and Cardiovascular Health N/A