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Choline Supplementation and Cardiovascular Health

Cardiovascular Risk Factor Clinical Trial

Official title:
Acute Choline Supplementation and Cardiovascular Health in Adults

Clinical Trial Summary

Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular disease (CVD) risk in some but not all cohort studies. The relevance of observations in animals to humans is unclear and little information is available on the mechanisms linking TMAO to increased CVD risk. Vascular dysfunction plays a critical role in the initiation and progression of atherothrombotic disease. Whether TMAO impairs vascular function in humans is not known. The purpose of this study is to determine if acute supplementation of dietary choline, which increases TMAO, impairs vascular function.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03646175
Study type Interventional
Source Virginia Polytechnic Institute and State University
Contact
Status Completed
Phase N/A
Start date September 19, 2018
Completion date November 21, 2023
View Details
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