Cardiovascular Disorders Clinical Trial
Official title:
A Multicenter, Open-label, 30-week Observational Clinical Study to Examine the Progress of Patients After Leaving the Cardiology Clinic or Unit Due to Acute Cardiovascular Event.
In western societies hypercholesterolemia is one of the major and independent factors that
predispose to cardiovascular disease and death from them. According to the clinical study
ATTICA, conducted during the years 2001-2002, in which randomized 1514 men and 1528 women,
rates of hypercholesterolemia observed in a sample of urban population was 39% for men and
37% women . The prevalence in the corresponding U.S. epidemiological study NIANES was 52%
for men and 49% women. The relationship between cholesterol, lipid-lowering therapy and risk
of cardiovascular disease appears to be quite clear in the secondary prevention trials, the
4S (Scandinavian Simvastatin Survival Study), CARE (Cholesterol And Recurrent Events) and
LIPID (Long-term Intervention with Pravastatin in Ischemic Disease) which showed the
benefits of lowering LDL cholesterol in patients with coronary artery disease. Despite these
remarkable results, studies were secondary prevention as a major shortcoming, the lack of
patients with acute coronary events. This gap came to cover the study MIRACL (Myocardial
Ischemia Reduction with Aggressive Cholesterol Lowering). In MIRACL study , atorvastatin 80
mg was evaluated in 3,086 patients (atorvastatin n = 1.538, placebo n = 1.548), acute
coronary syndrome (myocardial infarction without Q-wave or unstable angina). Treatment was
initiated during the acute phase after hospital admission and lasted for a period of 16
weeks. Treatment with atorvastatin 80 mg / day increased the latency of the combined primary
endpoint, defined as death from any cause, nonfatal myocardial infarction, resuscitated
cardiac arrest, or angina with objective evidence of myocardial ischemia requiring admission
to hospital, indicating a risk reduction of 16% (p = 0,048). This was mainly due to a 26%
reduction in re-hospitalization for angina with objective evidence of myocardial ischemia.
The other secondary endpoints were not statistically significant by themselves (total:
placebo: 22.2%, Atorvastatin: 22.4%).
Statins by reducing coronary syndromes, it appears that contribute to reducing the incidence
of cardiovascular diseases. This is exactly what was observed in 4S, in which the incidence
of chronic heart failure (CHF) during follow-up was 10.3% for those who received placebo and
8.3% in the simvastatin group, a finding which translates 19% reduction in heart failure (P
<0,015) nationwide with the appearance episode (event) CV.
Determination of cardiovascular risk
If the assessment of cardiovascular risk remains incomplete, can identify indicators that
measure risk:
1. Framingham Risk Score: Includes age, sex, total and HDL-CHOL, and levels of blood
pressure (can underestimate the risk in some patients).
2. PROCAM Risk Score: also includes triglycerides, fasting glucose tolerance and family
history.
3. Reynolds Risk Score: Includes family history and levels of hsCRP.
4. Greek Score (www.hearts.org / greece). People with low risk The Framingham Risk Score
shows <10% chance of cardiovascular disease over the next 10 years. Dealing mainly with
healthy dietary intervention or drugs when the levels of LDL-CHOL> 190 mg / dL or
atherogenic index (T-CHOL/HDL-CHOL)> 6.
Medication is necessary in individuals with familial hypercholesterolemia to reduce the LDL
CHOL <100 mg / dL. For this reason, a careful family history taking physical examination.
The Reynolds Risk Score may reclassify their low-risk patients at higher risk individuals.
Persons moderate risk This group includes mostly middle-aged people. The Framingham Risk
Score shows 10-19% chance of cardiovascular disease over the next 10 years. However, a
positive family history and high hsCRP (if available) can modify the level of risk. These
people need to change my lifestyle for 3 months, but may then be necessary pharmacological
lipid-lowering therapy in people with at least two major risk factors and levels of
LDL-CHOL> 130 mg / dL. The administration of lipid-lowering therapy in people with levels of
LDL-CHOL 100-129 mg / dL is recommended for people with multiple cardiometabolic risk
factors (visceral obesity, prediabetes, hypertension, etc.). The increase of atheromatic
index (> 5) and the presence of high (> 2 mg / L) levels of CRP (if available) are also
indications for lipid lowering regardless of the levels of LDL-CHOL.
Major risk factors: age> 45 years (men),> 55 years (women), positive family history of
premature cardiovascular disease [in the presence of major vascular events in first degree
relatives <55 years (men), <65 years (women)], hypertension , HDL-CHOL <40 mg / dL, smoking.
Individuals at high risk The Framingham Risk Score shows> 20% chance of cardiovascular
disease over the next 10 years. At-risk individuals include:
A. Individuals with documented atherosclerotic disease (coronary artery disease, stroke, a
significant degree of carotid stenosis, peripheral arterial disease, intermittent
claudication, or aneurysm of the abdominal aorta).
B. All type II diabetic patients and patients with type I diabetes individuals older than 40
years.
C. People with chronic kidney disease with glomerular filtration (GFR) <60 mL/min/1, 73 m2.
In these individuals need intensive lifestyle modification and direct administration lipid
lowering medication such as statins.
According to the above that one epidemiological study nature that has the purpose of
observing and recording the progress of patients after their exit from a cardiology clinic
or hospital unit because the acid after a cardiovascular event has clinical relevance.
Compliance with medical instructions, achieving treatment goals for lipids by the addition
of atorvastatin and personalized medicine practice are open field study. So this will be the
subject of this study in order to highlight the clinical significance of atorvastatin in
achieving the objectives of lipids (mainly LDL-CHOL) in blood plasma of "sensitive" of this
group of patients in the Greek population, as possible representative (qualitatively and
quantitatively)sample.
Dyslipidemia
The lipids of the human body is cholesterol (useful for the synthesis of cell membranes,
hormones adrenal and gonads, and is a component of bile, the liver secretes) and
triglycerides (serve as fuel and energy storage in adipose tissue ). The dyslipidemias are
disorders (quantitative or qualitative) of the metabolism of lipoprotein particles (LDL,
chylomicrons, HDL, VLDL) that transport lipids in the body.
Categories dyslipidemias - Primary dyslipidemias
The most significant primary lipid disorders are:
1. Chylomicronemia (congenital or acquired): ↑ TRG → risk of acute pancreatitis.
2. Familial Hypercholesterolemia a Homozygous (1/1.000.000 people): ↑ LDL CHOL b
heterozygous (1/500 people): ↑ LDL CHOL.
3. Mixed hyperlipidaemia Familial mixed (1/300 people): ↑ LDL-CHOL, ↑ TRG, ↓ HDL-CHOL.
4. Familial hypertriglyceridemia (1/2.000 people): ↑ TRG.
5. Familial decrease in HDL CHOL: ↓ HDL CHOL. Typically in patients with primary
dyslipidemia needed medication. - Secondary dyslipidemias
In patients with abnormal lipid parameters of must exclude secondary dyslipidemias, ie
disorders of lipid metabolism caused by diseases or drugs:
1. Diabetes
2. Hypothyroidism
3. Obstructive liver disease
4. Chronic kidney disease nephrotic syndrome-
5. Obesity
6. Alcohol abuse
7. Medications that cause dyslipidemia a progestin b Anabolic Steroids c Corticosteroids
D. Diuretics in large doses e b-blockers f Antiretroviral Drugs Interferon g h.
Retinoids Estrogen i tamoxifen. In patients with secondary dyslipidemia required
treatment of primary disease. Determination cohort for screening (Table 1)
- Men over 40 and post-menopausal women
- People with atherosclerotic disease regardless of age or clinical findings
suggestive of dyslipidemia
- Patients with diabetes regardless of age
- Patients with chronic kidney disease (eGFR <60 mL/min/1, 73 m2 or the presence of
albuminuria)
- People with a family history of premature coronary heart disease
- People with hypertension
- People with chronic inflammatory diseases (lupus erythematosus, rheumatoid
arthritis, psoriasis or acquired immunodeficiency syndrome)
- Adults who smoke
- adult with sexual dysfunction
- Overweight and obese subjects with BMI> 27 kg/m2
- Relatives of people with inherited lipid disorders
- Children with a family history of hyperlipidemia or cardiovascular disease or
other risk factors.
Statins - Atorvastatin
The cornerstone of treatment of dyslipidemia are statins.
Before initiation of lipid lowering requires the identification of lipid parameters {total
cholesterol, triglycerides, HDL cholesterol and calculated LDL cholesterol [from the
equation LDL-CHOL = total cholesterol - (triglycerides / 5 + HDL cholesterol)]} after
fasting 12 - 14 hours, while the determination of glucose levels of TSH (to exclude
underlying hypothyroidism) and transaminases (AST / ALT) and CPK to control the undesirable
effects. Repeat determination of these parameters in patients who achieved their goals of
treatment 2 times a year or when changing the therapeutic regimen. Repeat laboratory tests
(lipid control effectiveness and liver enzymes and CPK for security control) after 12 weeks:
a reason to discontinue treatment if ALT> 3 times the upper normal range or CPK> 5 times the
upper normal range or in patients with myalgias. It should be noted that not necessitate
interruption of treatment with statins or deferral of treatment in individuals with small
increases in transaminases or CPK, while in these patients should be seeking other
underlying causes of elevated liver and muscle enzymes. The choice of drug and dosage depend
on the percentage change in HDL-CHOL necessary to achieve the objectives. Statins are
usually the evening before bedtime the night. The lipid-lowering therapy is therapy for
life, and most importantly, the patient adherence to treatment. It should be noted that
doubling the dose of a statin results in additional reduction of HDL-CHOL (LDL) cholesterol
by 6%.
The main goal of treatment is to reduce HDL-CHOL
The non HDL-CHOL (= T-CHOL - HDL-CHOL), proposed as a secondary target of lipid lowering
mainly in people with high triglycerides. The target for the non HDL-CHOL is 30 mg / dL
higher than the target for the HDL-CHOL. The decrease in triglycerides (<150 mg / dL) and
increased HDL-CHOL (> 40 mg / dL for men and> 50 mg / dL for women) is considered desirable
targets mainly lipid lowering in diabetic patients and in patients with cardiometabolic risk
factors. Has also been suggested as a target of treatment to reduce the atheromatous index
(T-CHOL/HDL-CHOL <4).
Atorvastatin is indicated as an adjunct to diet to reduce elevated total cholesterol,
LDL-cholesterol, apolipoprotein B and triglycerides in adults, adolescents and children aged
10 years and older with primary hypercholesterolaemia, including heterozygous familial
hypercholesterolaemia combined (mixed) hyperlipidemia (type IIa and IIv by Fredrickson),
when response to diet and other nonpharmacological measures is inadequate.
Atorvastatin is also indicated to reduce total cholesterol and LDL - cholesterol in adults
with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering
treatments (eg LDL apheresis) or if such treatments are unavailable.
Is also used to prevent cardiovascular events in adult patients who are thought to have a
high risk for a first cardiovascular event, as an adjunct to correction of other risk
factors.
Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the enzyme
responsible for the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A to mevalonate, a
precursor of sterols, including cholesterol. The triglycerides and cholesterol in the liver
are incorporated into very low density lipoproteins (VLDL) and released into the plasma for
delivery to peripheral tissues. The low density lipoprotein (LDL) is formed from VLDL and is
catabolized primarily through receptor high affinity to LDL (LDL receptor).
Atorvastatin lowers cholesterol levels and lipoprotein plasma inhibiting HMG-CoA reductase
and then the biosynthesis of cholesterol in the liver and increase the number of LDL
receptors on the surface of liver cells which uptake and catabolism of LDL. Atorvastatin
reduces LDL production and the number of particles of LDL. H atorvastatin causes profound
and sustained increase of LDL receptor activity, in combination with a beneficial change in
the quality of the circulating particles of LDL. Atorvastatin effectively reduces LDL-C in
patients with homozygous familial hypercholesterolemia, a group of patients who do not
usually respond to lipid-lowering medicines.
Atorvastatin in a dose-response study, was shown to reduce the concentration of T-CHOL (30%
- 46%), the LDL-CHOL (41% - 61%), apolipoprotein B (34% - 50%) and triglycerides (14% - 33%)
while producing variable increases HDL-CHOL and apolipoprotein A1. These results are so
consistent in patients with heterozygous familial hypercholesterolaemia, non-familial forms
of hypercholesterolemia and mixed hyperlipidemia, including patients with
noninsulin-dependent diabetes mellitus.
It has been found that the decrease of the values of total cholesterol, LDL-CHOL and
apolipoprotein B reduces the risk of cardiovascular events and mortality thereof.
;
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