Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery

Cardiorenal Syndrome Clinical Trial

— DECONGEST  

Official title:

Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery: a Prospective Observational Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03684876
• Other study ID #: PI 2018_843_012
• Status: Recruiting
• Start date: June 1, 2018
• Est. completion date: June 1, 2024

Study information

• Verified date: May 2023
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: Osama ABOU ARAB, MD
• Phone: 33 3 22 08 78 36
• Email: AbouArab.Osama[@]chu-amiens.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow. The investigator's standard care includes use of diuretic to avoid interstitial fluid accumulation. The aim of the study is to assess cardiac and renal function before and after depletion by using diuretics

Description:

The study will compare cardiac and renal data before and 6 hours after use of diuretic

• Echocardiographic measure of right function (S wave, TAPSE, ventricle surfaces, inferior vena cava diameter) and left function (LVEF, cardiac output

• Renal function: cumulative diuresis, creatinine level variation and incidence of acute kidney injury using KDIGO classification (creatinine level>26.5 or diuresis<0.05 ml kg-1 h-1)

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: June 1, 2024
• Est. primary completion date: June 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

patient undergoing elective cardiac surgery under cardiopulmonary bypass

Exclusion Criteria:

• heart transplantation

• use of vasopressor

• chronic renal disease (DGF under 30 ml min-1)

• endocarditis

• patient under ECLS or CPIA

• patient under 18-year-old

Related Conditions & MeSH terms

• Cardio-Renal Syndrome
• Cardiorenal Syndrome
• Hyponatremia

Intervention

Procedure:
• diuretic use
use of diuretic

Locations

Country	Name	City	State
France	CHU Amiens Picardie	Amiens

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change in renal glomerular filtration before and 6 hours after use of diurectic	change in renal glomerular filtration before and 6 hours after use of diurectic	at baseline (o hours) and 6 hours after use of diuretic