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NCT03684876 Clinical Trial

Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery

Cardiorenal Syndrome Clinical Trial

— DECONGEST  

Official title:
Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery: a Prospective Observational Study

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03684876
Other study ID # PI 2018_843_012
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 1, 2018
Est. completion date June 1, 2024

Study information
Verified date May 2023
Source Centre Hospitalier Universitaire, Amiens
Contact Osama ABOU ARAB, MD
Phone 33 3 22 08 78 36
Email AbouArab.Osama@chu-amiens.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow. The investigator's standard care includes use of diuretic to avoid interstitial fluid accumulation. The aim of the study is to assess cardiac and renal function before and after depletion by using diuretics

Description:

The study will compare cardiac and renal data before and 6 hours after use of diuretic - Echocardiographic measure of right function (S wave, TAPSE, ventricle surfaces, inferior vena cava diameter) and left function (LVEF, cardiac output - Renal function: cumulative diuresis, creatinine level variation and incidence of acute kidney injury using KDIGO classification (creatinine level>26.5 or diuresis<0.05 ml kg-1 h-1)

Recruitment information / eligibility
Status Recruiting
Enrollment 40
Est. completion date June 1, 2024
Est. primary completion date June 1, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: patient undergoing elective cardiac surgery under cardiopulmonary bypass Exclusion Criteria: - heart transplantation - use of vasopressor - chronic renal disease (DGF under 30 ml min-1) - endocarditis - patient under ECLS or CPIA - patient under 18-year-old

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• diuretic use
use of diuretic

Locations
Country Name City State
France CHU Amiens Picardie Amiens

Sponsors (1)
Lead Sponsor Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary change in renal glomerular filtration before and 6 hours after use of diurectic change in renal glomerular filtration before and 6 hours after use of diurectic at baseline (o hours) and 6 hours after use of diuretic
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