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Cardiorenal Syndrome clinical trials

View clinical trials related to Cardiorenal Syndrome.

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NCT ID: NCT06174623 Not yet recruiting - Heart Failure Clinical Trials

Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistance

Start date: August 2024
Phase: N/A
Study type: Interventional

Evaluation of the safety and efficacy of the ModulHeart System in patients hospitalized with acute decompensated heart failure (ADHF) and diuretic resistance

NCT ID: NCT06111768 Recruiting - Clinical trials for Cardiorenal Syndrome

Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility Study

SGLT2i in CRS
Start date: May 30, 2024
Phase: Phase 2
Study type: Interventional

The long-term objective of this study is to test whether the addition of SGLT2 inhibitors to usual care during acute heart failure management in patients who develop kidney injury shortens the time to achieving symptomatic improvement and kidney function recovery. The study aims to assess feasibility and acceptability of such a randomized clinical trial.

NCT ID: NCT05927285 Completed - Acute Kidney Injury Clinical Trials

Effect on Kidney Function Recovery Guiding Decongestion With VExUS in Patients With Cardiorenal Syndrome 1

Start date: March 20, 2022
Phase: N/A
Study type: Interventional

During cardiorenal syndrome type 1 (CRS1) vascular congestion is the major contributor to worsening renal function, but promoting decongestion with routine clinical evaluation is ineffective in some patients. The venous evaluation by ultrasound (VExUS) may optimize its management when evaluating for improvement in kidney function and other metrics related to decongestion.

NCT ID: NCT05677100 Recruiting - Heart Failure Clinical Trials

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

DRAIN-HF
Start date: August 23, 2023
Phase: N/A
Study type: Interventional

Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and are resistant to diuretic therapy. Eligible ADHF patients with diuretic resistance (irrespective of ejection fraction) will be enrolled and randomized 1:1 to either the Aortix system or standard of care medical management.

NCT ID: NCT04917497 Completed - Cardiogenic Shock Clinical Trials

Levosimendan Infusion in Critically Ill Patients With Cardiogenic Shock

Start date: June 30, 2011
Phase:
Study type: Observational

To determine whether Levosimendan infusion in patients with cardiogenic shock and cardiorenal syndrome refractory to standard inotropic therapy, improves hemodynamics and renal function, whilst being safe.

NCT ID: NCT04589065 Suspended - Heart Failure Clinical Trials

SCD for CRS in Congestive Heart Failure (CHF) (No Left Ventricular Assist Device)

Start date: September 2024
Phase: N/A
Study type: Interventional

The purpose of this clinical trial is to see if a new device (SCD) is safe and if it can reduce damage to the kidney enough to allow medications to work to improve heart and kidney function for use in patients that have moderate to severe heart failure and is at least in part due to heart failure and it not responding to standard medical therapy. The SCD is a cartridge used with a commercial hemodialysis unit. Participants will be enrolled in the clinical trial once eligibility is confirmed. In addition to clinical assessments and laboratory testing participants will have surface echocardiograms during the trial. The SCD treatment will take place for 4 hours on day 1, 3, and 5 while on hemodialysis.

NCT ID: NCT04393493 Completed - Clinical trials for Cardiorenal Syndrome

The Effect in Renal Function on Patients With Type 1 Cardiorenal Syndrome Treated With Two Strategies of Furosemide.

Start date: July 1, 2017
Phase: Phase 2
Study type: Interventional

In double-blind clinical trial, determine renal recovery with two different furosemide strategies in patients with type 1 cardiorenal syndrome.

NCT ID: NCT04227977 Completed - Clinical trials for Cardiorenal Syndrome

Volume Optimization Incorporating Negative Pressure Diuresis in Heart Failure (VOID-HF)

VOID-HF
Start date: June 12, 2020
Phase: N/A
Study type: Interventional

The Cardiorenal Syndrome during Acute decompensated heart failure (ADHF) with persistent congestion despite high dose IV diuretic therapy is associated with remarkable morbidity, which can include the need for renal dialysis or ultrafiltration, an increased length of stay, and high mortality rates. The aims and purpose of this feasibility clinical research trial are: 1. to evaluate the safety profiles associated with performing negative pressure diuresis for the treatment of hypervolemia associated with the cardiorenal syndrome during ADHF with persistent congestion despite high dose IV diuretic therapy via the investigational JuxtaFlow® System, and 2. to evaluate the effectiveness of the investigational JuxtaFlow System in treatment of hypervolemia associated with ADHF.

NCT ID: NCT04145635 Completed - Heart Failure Clinical Trials

The Aortix CRS Pilot Study

Start date: February 5, 2021
Phase: N/A
Study type: Interventional

The Aortix CRS Pilot Study: An Evaluation of the Safety and Performance of the Aortix System for Intra-Aortic Mechanical Circulatory Support in Patients with Cardiorenal Syndrome

NCT ID: NCT04116034 Completed - Heart Failure Clinical Trials

Alfapump Direct Sodium Removal (DSR) Feasibility Study

RED DESERT
Start date: December 26, 2019
Phase: N/A
Study type: Interventional

First in Human feasibility and sfafety study of the alfapump DSR system in the treatment of Heart failure subects resistant to diuretic therapy. Up to 10 subjects will be enrolled in up to 3 centres in Belgium and Georgia and will be iplanted with the alfapump DSR system. Subjects will undergo DSR titration during a 2 week hospitalisation period, and will continue titrated DSR therapy as outpatients for 4 more weeks.