| Eligibility |
Inclusion criteria
- Female or male, aged between = 40 and =80 years
- Normal LVEF AND absence of akinetic segment assessed by echocardiography (i.e.
LVEF=50%)
- Patients diagnosed according to the specific diagnostic criteria of each disease (Cf.
table below (definition criteria)). For each group, the diagnosis will be based on
current accepted criteria:
- HFpEF: left ventricular ejection fraction (LVEF) LVEF=50% AND presence/or history
of symptoms (e.g. breathlessness, ankle swelling and fatigue) or signs (e.g.
elevated jugular venous pressure, pulmonary crackles and peripheral oedema) of
heart failure AND significant diastolic dysfunction (left atrial volume index >34
mL/m2 or a LVMI =115 g/m2 for males and =95 g/m2 for female, E/e' =13 and e' <9
cm/s) OR NT-proBNP >125 pg/Ml
- No HFpEF: LVEF=50% AND absence of symptoms (e.g. breathlessness, ankle swelling
and fatigue) or signs (e.g. elevated jugular venous pressure, pulmonary crackles
and peripheral oedema) of heart failure
- T2DM: HbA1c = 6.5% (= 48 mmol/L) AND Fasting Plasma Glucose =7.0 mmol/L (=126
mg/dL) or anti-diabetic treatment
- Non T2DM: HbA1c < 6.5% AND Fasting Plasma Glucose <7.0 mmol/L without any
anti-diabetic treatment including normoglycemic subjects
- HCM: patients with non-obstructive HCM of sarcomeric cause (proven with common
genetic cause) and with LV wall thickness = 15 mm in one or more myocardial
segments in the absence of abnormal afterload conditions.
- Suitable echocardiographic window
- Absence of history of coronary artery disease including history of myocardial
ischaemia, myocardial infarction or percutaneous coronary intervention
- Absence of significant coronary artery disease (CAD) defined as:
- the absence of coronary artery stenosis =50% on a cardiac computed tomography
(CT) OR a coronary angiography OR normal Fractional Flow Reserve (FFR >0.80) OR
- Coronary Artery Calcium score (CAC) <100 performed within the 48 months before
inclusion
- Patient covered by a health insurance
Non-inclusion criteria:
- Diabetes mellitus other than type 2 (type 1, LADA, MODY, NODAT, etc.)
- Suboptimal echocardiographic window
- Significant valvular heart disease defined as severe aortic regurgitation or severe
primary mitral regurgitation or aortic stenosis with a peak transvalvular velocity
=3m/s or mitral stenosis with a mitral valve area < 1.5cm²
- Chronic atrial fibrillation or any significant arrhythmia at inclusion
- Renal insufficiency defined as eGFR<30 mL/min/1.73m²
- History of and candidate to bariatric surgery
- Obstructive hypertrophic cardiomyopathy (definition: maximal gradient at rest <30
mmHg)
- Hypertrophic cardiomyopathy due to a non-sarcomeric etiology, i.e. known infiltrative
or storage disorder mimicking HCM such as Fabry disease or amyloidosis
- Life threatening comorbidities (i.e. history of or active cancer treated with
chemotherapy or radiotherapy, end-stage heart failure, severe lung disease, cirrhosis)
- Pregnancy/Lactating mother
- Any condition which in the Investigator's opinion makes it undesirable for the subject
to participate in the study or which would jeopardize compliance with the protocol
- Inability to understand the local language
- Individuals deprived of liberty
- Protected persons (under guardianship or curatorship)
- Contra-indication to CMR (please see CMR-SOP):
- Known hypersensitivity to gadolinium based product (including gadoteric acid and
meglumine)
- Known COVID-19 symptomatic infection requiring hospitalization
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