Diagnosis Of Early Cardiac Dysfunction in Patients With Idiopathic Frequent Monomorphic PVCs

Cardiomyopathies Clinical Trial

Official title:

Diagnosis Of Early Cardiac Dysfunction in Patients With Idiopathic Frequent Monomorphic PVCs and Effect Effect of Ablation and Comparison Between Different Sites of Ablation

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05105516
• Other study ID #: Cardiomyopathy in PVCs
• Status: Not yet recruiting
• Phase: N/A
• Start date: November 1, 2022
• Est. completion date: November 2025

Study information

• Verified date: June 2022
• Source: Assiut University
• Contact: Mohammed Usama
• Phone: +201013001256
• Email: mohammedusama502[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Diagnosis Of Early Cardiac Dysfunction in Patients With Idiopathic Frequent Monomorphic PVCs and effect of ablation and comparison between different sites of ablation

Description:

• Apply the speckle myocardial tracking technology to early diagnose dysfunction in patients with idiopathic frequent monomorphic PVCs

• Assessment of cardiac function before and after ablation and comparison before and after ablation and between sites of origin of the PVCs as diagnosed by the electrophysiologic and 3d mapping techniques that may be more confirmed by successful ablation whenever achieved

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 90
• Est. completion date: November 2025
• Est. primary completion date: November 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• All patients of sample size admitted to the cardiology department of Assiut university hospital for ablation of idiopathic frequent monomorphic PVCs

Exclusion Criteria:

• Patients with well-known factors of cardiac dysfunctions, including high blood pressure (over 140/90 mmHg), hypertrophic cardiomyopathy, left ventricular hypertrophy, bundle branch block, severe valvular disease, complete heart block, and previous CABG.

Related Conditions & MeSH terms

• Cardiomyopathies

Intervention

Procedure:
• Ablation
Ablation of ectopic foci causing PVCs

Locations

Country	Name	City	State
Egypt	Assiut University	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

References & Publications (2)

Latchamsetty R, Bogun F. Premature Ventricular Complex-Induced Cardiomyopathy. JACC Clin Electrophysiol. 2019 May;5(5):537-550. doi: 10.1016/j.jacep.2019.03.013. Review. — View Citation

Sharma E, Arunachalam K, Di M, Chu A, Maan A. PVCs, PVC-Induced Cardiomyopathy, and the Role of Catheter Ablation. Crit Pathw Cardiol. 2017 Jun;16(2):76-80. doi: 10.1097/HPC.0000000000000106. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	• Detection of early cardiac dysfunction in patients with idiopathic frequent monomorphic PVCs .	• Assessment of cardiac function in patients with idiopathic frequent monomorphic PVCs post - ablation and patients on medical treatment	Baseline