Clinical Trials Logo

Clinical Trial Summary

Pilot study to compare the impact of following a low-carbohydrate, high-fat diet versus following a high-carbohydrates, moderate-fat diet (UK dietary guidelines) on cardiometabolic risk markers and associated behaviours in a normal-weight and overweight adult population.


Clinical Trial Description

Cardiometabolic diseases (CMD), such as type 2 diabetes and cardiovascular disease (CVD), are globally amongst the highest contributors to morbidity and mortality with high (cost) implications to the overall economy and health care systems. A number of risk markers have been associated with CMDs, including blood serum markers, low levels of lean mass and high levels of body fat, including increased waist circumference. Dietary factors and nutritional status have long been linked with specific markers of cardiometabolic (CM) risk. The quantity and quality of dietary carbohydrates has been associated with increased serum triglycerides levels, increased body fat mass, increased waist circumference and visceral fat around the organs in particular. They also seem to increase food cravings. Whilst official dietary guidelines in the UK and elsewhere still recommend a high carbohydrate and low fat diet as standard, these recommendations have increasingly been challenged. Evidence has been mounting that very-low carbohydrate (ketogenic) and low carbohydrate diets can ameliorate CM risk factors, especially when a personalised rather than a one-size-fits-all approach is being taken. Response to carbohydrate load and adherence to dietary interventions can vary widely dependent on individual substrate and energy metabolism and insulin-resistant status.

The majority of dietary interventions with ketogenic and low-carbohydrate diets has focused on weight loss as the primary outcome in overweight and obese individuals. However, in recent years evidence has been mounting that the location and quality of adipose tissue (AT) play a more important role in manifestation of CM risk than quantity of AT alone. Detrimental health behaviours, such as low-quality diet and low levels of physical activity seem to be important contributors to this.

Further studies can provide vital insights into the links between diet, location-specific adipose tissue, CM risk factors and health-related behaviours.

Therefore this 8-weeks randomised pilot study will investigate the impact of either following a low-carbohydrate, high-fat diet versus following a high-carbohydrates, moderate-fat diet (UK dietary guidelines) on cardiometabolic risk markers and associated behaviours in a normal-weight and overweight adult population aged 19 - 64 at potential risk of CMD. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03257085
Study type Interventional
Source Liverpool John Moores University
Contact
Status Completed
Phase N/A
Start date March 9, 2017
Completion date December 8, 2017

See also
  Status Clinical Trial Phase
Completed NCT02599272 - Effects of Mixed Spices on Cardiometabolic Function - the PolySPice (PSP) Study N/A
Completed NCT03731013 - Combining a Mediterranean Diet With Physical Activity to Address Cardiometabolic Risk N/A
Completed NCT03839212 - The Happy Older Latinos Are Active (HOLA) Health Promotion Study in HIV-Infected Latino Men N/A
Completed NCT03773900 - Characterization of Gut Microbiota Composition and Activity After a Daily Supplementation of 4.5 g/Day of ChitinGlucan Fibre During 3 Weeks in At-cardiometabolic Risk Volunteers N/A
Completed NCT05771571 - Investigation of the Acute Effect of Novel Olive Oil on Postprandial Oxidative Stress Biomarkers (BioliveCT) N/A
Active, not recruiting NCT04902417 - Dairy and Inflammation Study N/A
Completed NCT02099032 - Milk Polar Lipids Consumption, Lipid Metabolism, and Inflammation in Menopausal Women N/A
Completed NCT01467544 - Reduce Cardiovascular Risk in Women Through Tai Chi Intervention N/A
Completed NCT04011995 - Effects of Intermittent Caloric Restriction in Youth With Cardiometabolic Risk N/A
Completed NCT04190706 - Synergistic Innovative Functional Food Concepts to Neutralize Inflammation for Cardiometabolic Risk Prevention N/A
Completed NCT03274739 - Maternal Diet, Body Mass Index Trajectories and Cardiometabolic Risk in Early Childhood
Recruiting NCT05400005 - Impact of Different Types of Higher Dietary Protein Intake on Sleep Quality in Singapore Older Adults N/A
Terminated NCT04737044 - Effects of Antioxidant Sugar vs Granulated Sugar on Metabolic Outcomes in Healthy and Cardio Metabolic Subjects N/A
Completed NCT05228925 - GraviD-child Follow-up of the Children´s Health, Growth and Development Within the GraviD-study
Completed NCT04275440 - Effects of Caloric Restriction and Exercise on Body Weight, Immune Function, and Intestinal Flora N/A
Withdrawn NCT04359433 - Intermittent Exercise Among Students N/A
Completed NCT02146339 - Impact of Milk Polar Lipids on Lipids Digestion, Absorption and Metabolism N/A
Recruiting NCT04834687 - Effects of Diet and Exercise Interventions on Cardiometabolic Risk Markers, Executive Function, and Intestinal Flora N/A