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Dexmedetomidine and the Inflammatory Response in Pediatric Cardiac Surgery

Cardiac Surgical Procedures Clinical Trial

Official title:
The Effect of Dexmedetomidine on the Inflammatory Response in Children Under Congenital Heart Disease Repair With Cardiopulmonary Bypass: A Randomized Controlled Clinical Trial

Clinical Trial Summary

Cardiopulmonary bypass-assisted surgery initiates a systemic inflammatory response induced by extrinsic (e.g. anesthesia, contact activation within the extracorporeal circuit, endotoxemia) and intrinsic (e.g. tissue damage, endothelial cell activation, ischemia-reperfusion injury of myocardium) factors. This may either be mild or lead to a more severe clinical condition. Inflammation after pediatric open heart surgery is a parameter affecting also duration of mechanical ventilatory support. Dexmedetomidine use was associated with a reduced increase in plasma IL-1, IL-6, TNF-a, and INF-g levels

Clinical Trial Description

Dexmedetomidine will be used during Cardiopulmonary bypass-assisted surgery for pediatric cardiac surgery ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03163238
Study type Interventional
Source Assiut University
Contact Sayed K Abd-Elshafy, MD
Phone 0882293592
Email sayed_k_72@yahoo.com
Status Recruiting
Phase Phase 2
Start date May 30, 2017
Completion date December 2018
View Details
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