Clinical Trials Logo
  1. Home
  2. Cardiac Surgical Procedures
  3. NCT03163238

Dexmedetomidine and the Inflammatory Response in Pediatric Cardiac Surgery

Cardiac Surgical Procedures Clinical Trial

Official title:
The Effect of Dexmedetomidine on the Inflammatory Response in Children Under Congenital Heart Disease Repair With Cardiopulmonary Bypass: A Randomized Controlled Clinical Trial

Clinical Trial Summary

Cardiopulmonary bypass-assisted surgery initiates a systemic inflammatory response induced by extrinsic (e.g. anesthesia, contact activation within the extracorporeal circuit, endotoxemia) and intrinsic (e.g. tissue damage, endothelial cell activation, ischemia-reperfusion injury of myocardium) factors. This may either be mild or lead to a more severe clinical condition. Inflammation after pediatric open heart surgery is a parameter affecting also duration of mechanical ventilatory support. Dexmedetomidine use was associated with a reduced increase in plasma IL-1, IL-6, TNF-a, and INF-g levels

Clinical Trial Description

Dexmedetomidine will be used during Cardiopulmonary bypass-assisted surgery for pediatric cardiac surgery ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03163238
Study type Interventional
Source Assiut University
Contact Sayed K Abd-Elshafy, MD
Phone 0882293592
Email sayed_k_72@yahoo.com
Status Recruiting
Phase Phase 2
Start date May 30, 2017
Completion date December 2018
View Details
See also
  Status Clinical Trial Phase
Terminated NCT04293744 - Acute Kidney Injury After Cardiac Surgery N/A
Completed NCT01184521 - Masimo CO-Oximeter Study Phase 0
Completed NCT05537168 - Bayesian Networks in Pediatric Cardiac Surgery
Completed NCT05737147 - Comparison of the Accuracy and Precision of a Zero Heat Flux Thermometer (SpotOn) Versus Pulmonary Artery Temperature.
Completed NCT04269109 - Opioid Sparing Pain Management Strategy
Completed NCT04911413 - Comparison of Three Tranexamic Acid Dose Regimens in Patients Undergoing Cardiac Valve Surgery Phase 4
Recruiting NCT02580292 - Diagnostic Accuracy of Doppler Resistive Indices for Early Diagnosis of Acute Kidney Injury .
Completed NCT02457572 - Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition N/A
Completed NCT00997217 - The Effect of Remote Ischemic Preconditioning in the Cardiac Surgery Phase 1
Recruiting NCT05454735 - Glycemic Variability and Autonomic Nervous System in Cardiac Surgery Patients
Completed NCT01169441 - Lead Extract Study N/A
Completed NCT00336908 - Inflammatory Responses to Lipid Emulsions in Children Before and After Open Heart Surgery Phase 2/Phase 3
Terminated NCT05308589 - CPPF After Cardiac Surgery in High Risk Patients N/A
Completed NCT02329158 - Disinvestment in Hydroxyl-ethyl Starches (HES) for Cardiac Surgery
Completed NCT01029314 - Pilot Study of the Genius(TM)2 Tympanic Thermometer in Cardiac Patients Requiring Cardiopulmonary Bypass N/A
Completed NCT00459082 - A Pharmacokinetic Study of Dexmedetomine in Infants Phase 1
Completed NCT00122018 - An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery Phase 2
Terminated NCT03709693 - Clinical Outcomes in Patients Treated With SternaLock Blu
Completed NCT03976947 - Impact of Lung Recruitment Maneuvers on Driving Pressure in Cardiac Surgery
Completed NCT02398019 - Clinical Trial to Evaluate the Use of an Adsorption Membrane (oXiris®) During Cardiopulmonary Bypass Surgery N/A