Cardiac Output Clinical Trial
Official title:
Impact of Pacing Mode and Diastolic Function on Cardiac Output
Background It is known from previous research that in patients with complete AV
(atrioventricular) block and pacemaker stimulation stroke volume and cardiac output are
higher with AV-synchronous than with AV-dyssynchronous pacing. However, the extent to which
patients profited from AV-synchronous stimulation varied substantially.
Aim of the study Aim of this study is to systematically analyze the impact of diastolic
function and other echo parameters on the difference of stroke volumes/cardiac output between
AV-synchronous and AV-dyssynchronous pacing modes.
Methods Patients fulfilling the entry criteria will be enrolled (two-chamber pacemaker of any
vendor eligible) in this monocentric, prospective, interventional study. Baseline data will
be collected with a standardized questionnaire. During an echo examination, parameters of
diastolic, systolic and atrial function will be assessed. Then, the stroke volume/cardiac
output will be measured twice in each patient, once with AV-synchronous and once with
AV-dyssynchronous pacing. Therefore, each patient will represent their own control. It will
be randomized (coin tossing) which stimulation mode is first and which is second (sonographer
and patient will be blinded). Descriptive statistics will be applied and regression models
will be fitted to explore the data.
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