Cardiac Output, Low Clinical Trial
Official title:
Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy
Open-heart surgery causes injury of the heart muscle. Although this is usually mild,
temporary and reversible, if it is severe it can endanger life and require additional high
cost care. During surgery, techniques are used to protect the heart from injury, but these
remain imperfect. Patients with a thickened wall of the heart (left ventricular hypertrophy)
may be at greater risk. This study assesses the effect of facilitating sugar metabolism (a
more efficient fuel) by the heart muscle using the drug Perhexiline given before the
operation.
This treatment has a sound experimental basis for improving outcome. If this improvement is
confirmed surgical results could be improved. The investigators will be studying heart
function, heart muscle energy stores and chemicals which quantify the amount of heart muscle
injury. The investigators' hypothesis is that Perhexiline will improve the protection of the
heart by decreasing damage that may occur during heart surgery.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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