Clinical Trials Logo
  1. Home
  2. Cardiac Ischemia
  3. NCT05164640

Ischemia in Patients With Non-obstructive Disease (INOCA) in Italy INOCA IT Multicenter Registry" — INOCAIT  

Cardiac Ischemia Clinical Trial

Official title:
Ischemia in Patients With Non-obstructive Disease (INOCA) in Italy INOCA IT Multicenter Registry"

Clinical Trial Summary

Prospective, interventional, multicentre, non-randomized, single-arm open-label study that aims to enroll 200 consecutive patients with suspected chronic ischemic heart disease in the absence of obstructive coronary artery disease (INOCA) at clinically indicated coronary angiography in 3 Italian centers. During coronary angiography, these patients will be simultaneously subjected to a functional and coronary physiology study (according to the methods reported below): - Functional evaluation with fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), Resting Full-Cycle Ratio (RFR) of angiographic stenosis> 50%; - In the presence of coronary angiographic stenosis <50% or> 50% but in the presence of a negative functional assessment (FFR> 0.80 and iFR / RFR> 0.90), coronary flow reserve (CFR) and index of microvascular resistance (IMR) will be measured. IMR and CFR will be assessed using intra-coronary guidance; - In the presence of CFR> 2.0 and IMR <25, tests with acetylcholine will also be performed in order to evaluate the possible presence of epicardial (focal or diffuse) or microvascular spasm.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05164640
Study type Interventional
Source IRCCS San Raffaele
Contact
Status Completed
Phase N/A
Start date December 1, 2021
Completion date February 29, 2024
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06154473 - Assessment of Patients Undergoing Cardiac Surgery and Admitted to the Intensive Care Unit
Completed NCT03203057 - Induced Myocardial Ischemia: a Serial Troponin T and Troponin I Measurements N/A
Active, not recruiting NCT06235424 - Del Nido Versus HTK Cardioplegia in Adult Aortic Valve Replacement Phase 4
Completed NCT03859466 - Safety and Efficacy of Cardiac Shockwave Therapy in Patients Undergoing Coronary Artery Bypass Grafting N/A
Recruiting NCT04749212 - Perioperative Troponin I and NT Pro-BNP in Lung Resection
Recruiting NCT03798652 - Improved Prediction of Functional Recovery After Revascularisation Using Combined Assessment of Myocardial Ischaemia and Viability by CMR - Pilot Study
Recruiting NCT05726604 - 4D CT Scan Versus 3D CT Scan Concerning Cardiac Dosimetry Assesment for Left Sided Breast Cancers Radiotherapy N/A
Completed NCT04458155 - Li-Hep vs. Non-Li-Hep Coated Transfer Device
Not yet recruiting NCT06414330 - Ringer Acetate Based Modified Del Nido Cardioplegia Solution Versus HTK Solution Cardioplegia Solution in Cardiac Surgery N/A
Completed NCT02055443 - Myocardial Ischemia Detection for Early Identification of Patients With Ischemic Chest Pain N/A
Completed NCT03053128 - Implication of Cardiac Shock Wave Therapy on Coronary Artery Disease N/A
Completed NCT03433963 - The Use of L-arginine to Mitigate the Cardiovascular Effects of Exposure to Traffic-related Air Pollution N/A
Recruiting NCT05757947 - Study of the No-touch Saphenous Vein Graft N/A
Completed NCT03642730 - Interactive Guided Ultrasound Examinations Done by Non-experts of Ultrasound Imaging N/A
Recruiting NCT05006183 - Instantaneous Wave-free Ratio Guidance Strategy Evaluation in the Treatment of Multivessel Acute Coronary Syndrome. N/A
Active, not recruiting NCT05453097 - Prognostic Value of the Selvester QRS Score for Perioperative Myocardial Injury Following Non-cardiac Surgery
Recruiting NCT03800082 - Development and Usability Testing of a Progressive WebApp for Women With Heart Disease N/A
Completed NCT03857503 - Radiographic Imaging Validation and EvALuation for Angio iFR (ReVEAL iFR)