Cardiac Failure Clinical Trial
— TEP-READ
In patients with heart failure, the drive to the effort has demonstrated its safety and its
interest. Patients with heart failure, endothelium-dependent peripheral vasodilatation is
impaired by decreased activity of endothelial NO synthase. The rehabilitation training
significantly improves peripheral endothelial function, and this improvement is correlated
to the increase in exercise capacity. The impact on coronary endothelial function remains
poorly documented, especially in non-ischemic dilated heart disease.
The main objective of this study is to investigate the effectiveness of cardiac
rehabilitation on the restoration of coronary endothelial function in cardiac failure
patient evaluated with Tomography Positron Emission 15O-H2O.
Status | Completed |
Enrollment | 54 |
Est. completion date | November 2015 |
Est. primary completion date | November 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients with heart failure with nonischemic dilated cardiomyopathy - Class II-III NYHA (New York Heart Association) - Having no contra-indication to the effort - Fraction Ejection = 40% - patient who will have cardiac rehabilitation - Age over 18 years - informed consent signed - patient with a social security scheme Exclusion Criteria: - Hypertension> 160/90 mmHg - High cholesterol level > 6.0 mmol / l - Diabetes known and treated - Active smoking - Valvular heart disease, congenital or ischemic - Pregnant or breastfeeding women - Age <18 years - Major Adult guardianship |
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
France | Service de Cardiologie | Caen |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Caen |
France,
Legallois D, Belin A, Nesterov SV, Milliez P, Parienti JJ, Knuuti J, Abbas A, Tirel O, Agostini D, Manrique A. Cardiac rehabilitation improves coronary endothelial function in patients with heart failure due to dilated cardiomyopathy: A positron emission — View Citation
Tuffier S, Legallois D, Belin A, Joubert M, Bailliez A, Redonnet M, Agostini D, Manrique A. Assessment of endothelial function and myocardial flow reserve using (15)O-water PET without attenuation correction. Eur J Nucl Med Mol Imaging. 2016 Feb;43(2):288 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rate of myocardial blood flow during the cold test | change over baseline and after 3 month | No |
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