Cardiac Disease Clinical Trial
Official title:
Role of Atrial Natriuretic Peptide in Assessing of Fluid Status in Cardiac Surgery Patients
Verified date | September 2022 |
Source | Petrovsky National Research Centre of Surgery |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Biomarkers can play a significant role in fluid status assessment intraoperatively.
Status | Completed |
Enrollment | 27 |
Est. completion date | April 7, 2022 |
Est. primary completion date | March 28, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: CABG, one-, two valve repair/replacement, ascending aorta, aortic arch replacement, ASD/AVD closure, septal myectomy Exclusion Criteria: 1. Atrial fibrillation, atrial flutter, frequent ventricular and supraventricular arrythmias 2. EFLV < 50% 3. Pulmonary hypertension > 2 st 4. CKD > C3 (GFR < 30) 5. Redo surgery 6. Left atrium volume > 150 ml 7. LV EDV > 250 ml |
Country | Name | City | State |
---|---|---|---|
Russian Federation | Petrovsky Research National Centre of Surgery (Petrovsky NRCS) | Moscow |
Lead Sponsor | Collaborator |
---|---|
Petrovsky National Research Centre of Surgery |
Russian Federation,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of patients with CI rise > 10% after PLR maneuver | 2 stages of Teboul test assessment | intraoperatively | |
Primary | Number of patients with pro-ANP twofold raise by the end of surgery | To assess the atria strain and consequent rise of pro-ANP by the end of surgery | intraoperatively | |
Primary | Number of patients with pro-ANP increase > 10% by the PLR maneuver | According to positive PLR the assessment of pro-ANP consequent raise | intraoperative | |
Secondary | Postoperative complications | Total amount of various postoperative complications | up to 10 days | |
Secondary | Mortality | Mortality rate | up to 10 days | |
Secondary | Multiorgan failure | Number of more than 2 organs failure | up to 10 days | |
Secondary | Respiratory failure | Number of patients who require prolonged and/or repeated artificial lung ventilation | up to 10 days | |
Secondary | Renal failure | Number of patients who require extracorporeal detoxication | up to 10 days | |
Secondary | Heart failure | Need in medicamental cardiotonic support more than 1 day | up to 10 days | |
Secondary | Circulatory insufficiency | Need in medicamental vasopressor support more than 1 day | up to 10 days | |
Secondary | Infection rate | Number of patients who develop systemic infection and/or operation wound infection | up to 10 days | |
Secondary | Length of intensive care stay | Duration of summarized length in ICU, including readmission to ICU | up to 10 days |
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