Arterial Blood Pressure and Cardiac Arrest — ABaCAS  

Cardiac Arrest Clinical Trial

Official title: Arterial Blood Pressure and Cardiac Arrest

Status Not yet recruiting

Clinical Trial Summary

To describe and measure diastolic and systolic femoral arterial pressure during medical cardiac arrest.

To define baseline measures. To describe and measure arterial blood pressure after placement of an ITD device.

To observe the diastolic pressure immediately prior to return of spontaneous circulation.

To quantify and describe the effects of intravenous adrenaline on arterial blood pressure in cardiac arrest.

Clinical Trial Description

Cardiac arrest is a complex disorder whose outcome is reliant on a huge number of factors. Moreover, many interventions are time critical, therefore an intervention that may be lifesaving if given early, may have no benefit if instigated further in the disease course. For these reasons' studies involving cardiac arrest are incredibly difficult to carry out and interpret. Many of the interventions carried out during cardiac arrest are aimed at improving blood pressure and thereby increasing the amount of blood and oxygen delivered to the myocardium in the hopes of achieving a return of spontaneous circulation (ROSC). However current data on what a 'normal' blood pressure, based largely upon non-invasive measurement, during cardiac arrest is severely limited, making comparison and evaluation of interventions extremely difficult. This provides the basis for this study in order to prospectively collate and describe data from invasive blood pressure monitoring during adult, medical cardiac arrest in the pre-hospital environment.

3. Research Question/Aim(s) To measure and describe femoral arterial pressure during cardiac arrest with mechanical CPR by a LUCAS device. 3.1 Objectives Primary objective To quantify and describe baseline arterial systolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting. This will be defined as a line of best fit for systolic blood pressure superimposed on the arterial trace during a 3 minute period.

Secondary Objectives

• To quantify and describe baseline arterial diastolic blood pressure as measured by an invasive femoral line in adult patients suffering medical cardiac arrest in the pre-hospital setting. This will be defined as a line of best fit for diastolic blood pressure superimposed on the arterial trace during a 3 minute period.

• To quantify and describe arterial blood pressure after the placement of an ITD device over a 3 minute period.

• To quantify and describe the effect of intravenous adrenaline on blood pressure as administered in line with ALS guidelines (every 3-5 mins) in adult patients in cardiac arrest.

• To document the diastolic blood pressure of those patients that achieve return of spontaneous circulation (ROSC) following out of hospital cardiac arrest. ;

Related Conditions & MeSH terms

• Cardiac Arrest
• Heart Arrest

• NCT number: NCT06443567
• Study type: Observational
• Source: Manchester University NHS Foundation Trust
• Contact: ian tyrrell-marsh, MBChB
• Phone: 01612761234
• Email: ian.tyrrell-marsh@mft.nhs.uk
• Status: Not yet recruiting
• Start date: June 2024
• Completion date: June 2025