Feasibility of TEE During Cardiac Arrest in Dutch Emergency Departments

Cardiac Arrest Clinical Trial

Official title:

Feasibility of Transesophageal Echocardiography in Patients With Cardiac Arrest in Emergency Departments in the Netherlands

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06249035
• Other study ID #: EDTEE2024
• Status: Not yet recruiting
• Phase: N/A
• Start date: April 1, 2024
• Est. completion date: May 1, 2025

Study information

• Verified date: January 2024
• Source: Medical Centre Leeuwarden
• Contact: Peter Veldhuis, MD
• Phone: +3158 286 6666
• Email: peter.veldhuis[@]mcl.nl
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this feasibility study is to learn if Dutch ED providers are able to use transesophageal echocardiography during cardiac arrest.

The main question it aims to answer is:

• are the ED providers able to determine the area of maximal compression of the heart using TEE

Description:

Point-of-care ultrasound is a valuable diagnostic tool during cardiopulmonary resuscitation (CPR) in cardiac arrest and its use is recommended by international guidelines. Transthoracic echocardiography (TTE) is most commonly used, but has certain limitations. Image acquisition can be challenging due to patient specific factors such as body habitus. Also image quality may be impacted by the limited acquisition time during CPR pulse checks. Furthermore, observational data suggests that pulse checks are prolonged due to TTE, while minimizing interruption of chest compressions is emphasized for better CPR outcomes in the guidelines. Transesophageal ultrasound (TEE) is a possible alternative for TTE. It has the theoretical advantage of superior image quality and thereby possible reductions of chest compression delays. Furthermore, TEE gives the opportunity determine which part of the heart is compressed most effectively, which is referred to as the area of maximal compression (AMC). Animal studies showed that an AMC located over the left ventricle positively influenced hemodynamics and return of spontaneous circulation (ROSC) compared to an AMC over the aortic root. In human studies, data also suggests that AMC located on the left ventricle, as measured by TEE, may positively influence prognosis.

In the Netherlands, TEE is currently not used in emergency departments during cardiac arrest. The purpose of this study is to investigate if point-of-care TEE can be used effectively and safely by providers and teams that have not previously used this modality. Given the paramount importance of quality of chest compressions, the ability of the providers to assess the location of the AMC will be the main focus of this feasibility study.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 30
• Est. completion date: May 1, 2025
• Est. primary completion date: April 1, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients with cardiac arrest > 18 year in the emergency department.

Exclusion Criteria:

• Patients with known upper gastro-intestinal malignancy or strictures, previous upper gastro-intestinal surgery or radiation, or known esophageal varices.

• Patient with a do-not-resuscitate order, pregnant patients and traumatic cardiac arrest.

• No trained TEE provider available.

• ROSC at arrival.

• Decision by the team to stop resuscitation at arrival at the emergency department due of prognosis.

• Other life saving interventions which are prioritized over TEE by the resuscitation team.

Related Conditions & MeSH terms

• Cardiac Arrest
• Emergencies
• Heart Arrest

Intervention

Diagnostic Test:
• Transoesophageal echocardiography (TEE)
TEE is a diagnostic modality in which an ultrasound probe is inserted via the oesophagus in order to visualize the heart.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Medical Centre Leeuwarden	Onze Lieve Vrouwe Gasthuis

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Area of maximal compression (AMC)	The percentage of patients in which providers are able to determine the location of the AMC during cardiac arrest.	First 30 minutes of cardiac arrest treatment in the ED.
Secondary	Location of AMC	The echographic location of the AMC, subcategorised as: left ventricle, left ventricular outflow tract/aortic root, other, not able to determine AMC	First 30 minutes of cardiac arrest treatment in the ED.
Secondary	Accuracy of AMC	Accuracy of AMC defined as correlation between providers interpretation of AMC and reviewers interpretation of AMC	First 30 minutes of cardiac arrest treatment in the ED.
Secondary	Safety of TEE	Incidence of complications of TEE	First 30 minutes of cardiac arrest treatment in the ED.
Secondary	Intubation	Need for intubation for using TEE and duration of intubation	First 30 minutes of cardiac arrest treatment in the ED.
Secondary	Time to image	Time from start ED treatment to first TEE image	First 30 minutes of cardiac arrest treatment in the ED.