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Beta-blockade With Landiolol in Out-of-hospital Cardiac Arrest — Beta-Arrest  

Cardiac Arrest Clinical Trial

Official title:
Beta-blockade With Landiolol in Out-of-hospital Cardiac Arrest: a Randomized, Double-blind, Placebo-controlled, Pilot Trial

Clinical Trial Summary

This study investigates the efficacy of landiolol versus placebo in patients with out-of-hospital cardiac arrest (OHCA) and refractory ventricular fibrillation (electrical storm).

Clinical Trial Description

The use of beta-blockers in OHCA patients with refractory VF could potentially reverse the unwanted beta-1-mediated effects of endogenous and exogenous epinephrine (proarrhythmic effect), which could in turn lead to a shorter time until return of spontaneous circulation (ROSC). This is a prospective, double-blind, randomized placebo-controlled pilot trial. The investigators consider this a pilot trial, as this is the first prospective trial evaluating the use of beta-blockade in cardiac arrest. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05554978
Study type Interventional
Source Medical University of Vienna
Contact Georg Gelbenegger, MD
Phone +43140400
Email georg.gelbenegger@meduniwien.ac.at
Status Recruiting
Phase Phase 1/Phase 2
Start date March 3, 2021
Completion date December 31, 2023
View Details
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