Cardiac Arrest Clinical Trial
— DOTACOfficial title:
Doppler Sonography of Cerebral Blood Flow for Early Prognostication After Out-of-hospital Cardiac Arrest: the DOTAC Study
NCT number | NCT03270683 |
Other study ID # | 35RC16_3047_DOTAC |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | May 2, 2016 |
Est. completion date | October 2017 |
Verified date | December 2019 |
Source | Rennes University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Objective: To assess neurologic prognostication by early Transcranial Doppler Sonography
(TCD) in comatose survivors after cardiac arrest.
Design: Prospective study between May 2016 and November 2017 in a medical intensive care unit
and cardiac intensive care unit in a university hospital.
Patients: all comatose patients older than 18 years successfully resuscitated from an
out-of-hospital cardiac arrest (OHCA). Patients for whom OHCA is associated with traumatic
brain injury, no window for TCD measurements, or dead before neurological prognostication are
excluded.
Status | Completed |
Enrollment | 52 |
Est. completion date | October 2017 |
Est. primary completion date | October 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - older 18 years - out-of-hospital cardiac arrest with recovery of spontaneous cardiac activity Exclusion Criteria: - transcranial doppler not done or not interpretable - associated cranial trauma - died without neurological assessment |
Country | Name | City | State |
---|---|---|---|
France | CHU Rennes | Rennes |
Lead Sponsor | Collaborator |
---|---|
Rennes University Hospital |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evaluate the relation between TCD measurements and neurologic outcome at hospital discharge | Good score = CPC 1-2 and bad score = CPC 3-5 | 6 months | |
Secondary | Measurement of pulsatility index | Evaluate the association between pulsatility index and period of cardiac arrest | 12 hours | |
Secondary | Entry of doppler parameters | Identify a doppler parameter than can improve the neurological outcome | 6 months |
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