Cardiac Arrest Clinical Trial
Official title:
Doppler Sonography of Cerebral Blood Flow for Early Prognostication After Out-of-hospital Cardiac Arrest: the DOTAC Study
Objective: To assess neurologic prognostication by early Transcranial Doppler Sonography
(TCD) in comatose survivors after cardiac arrest.
Design: Prospective study between May 2016 and November 2017 in a medical intensive care unit
and cardiac intensive care unit in a university hospital.
Patients: all comatose patients older than 18 years successfully resuscitated from an
out-of-hospital cardiac arrest (OHCA). Patients for whom OHCA is associated with traumatic
brain injury, no window for TCD measurements, or dead before neurological prognostication are
excluded.
The investigators measure the pulsatility index (PI) and diastolic flow velocity (DFV) of the
right and left middle cerebral artery during the first 12 h after return of spontaneous
circulation (ROSC). The highest value of DFV and the lowest of PI will use for the
statistical analysis. Cerebral Performance Category evaluate neurologic outcome at hospital
discharge.
Data provided by early TCD after ROSC are associated with neurological outcome. The use of
these data could lead to the development of therapeutics improving cerebral perfusion in
patient resuscitated from an OHCA.
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