Cardiac Arrest Clinical Trial
Official title:
Therapeutic Hypothermia After Cardiac Arrest in Non Shockable Rhythm at Rescue Arrival: The HYPERION Study
Cardiac arrest is at present a major cause of mortality as well as a cause of disability for
the surviving victims.In Europe, every year counts as 300,000 cardiac arrests responsible for
250,000 deaths. Thus, less than 20 % of patients discharged home with impaired quality of
life associated with symptoms of tiredness, stress, anxiety. The prognosis is related to the
initial cardiac rhythm present during the initiation of resuscitation. Recent progress in the
improvement of mortality and neurological outcome has been achieved over the last decade
thanks to the systematic implementation of a period of targeted temperature control between
32 and 34 ° C in patients who benefited from the realization of at least one electrical
external shock.
There are theoretical and clinical arguments to think that achieving the same way a period of
targeted temperature control between 32 and 34 ° C in patients treated for cardiac arrest
with a non- shockable rhythm on arrival can also benefit from this procedure. However other
arguments are against this hypothesis including an increase in the risk of infection ,
worsening of the patient's hemodynamic status with no benefit to him. To answer this
question, we conduce a randomized multicenter study testing the potential improvement of
neurological outcome through this procedure targeted temperature control between 32.5 and
33.5 ° C in these patients.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
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Phase 3 |