Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients

Cardiac Arrest Clinical Trial

Official title:

Evaluating the Quality of Prehospital and In-hospital Cardio-pulmonary Resuscitation - Comparing the Compressions to Concurrent Vital Signs (Invasive Blood Pressure, Cerebral Oxygen Saturation, EtCO2) and Iatrogenic Injuries Associated to Chest Compressions.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00951704
• Other study ID #: R08116
• Status: Completed
• Start date: November 2008
• Est. completion date: December 2018

Study information

• Verified date: December 2018
• Source: Tampere University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The prognosis of cardiac arrest patients is generally poor. Recent studies have showed that the high quality of CPR increases the survival after cardiac arrest. Therefore the investigators planned this prospective observational study to determine the epidemiology of sudden cardiac arrest in the prehospital setting of Tampere area, the quality of the CPR, and also the associations between depth and frequency of chest compressions and invasive arterial pressure, EtCO2,cerebral oxygenation and iatrogenic injuries associated to chest compressions 1) in patients resuscitated out of hospital by emergency medical service's (EMS's) personals and 2) in-hospital by hospital resuscitation team members. In addition, the investigators will analyze the effects of the chosen method of resuscitation on critical vital signs (Etco2 and invasive pressures): closed-chest CPR is compared to open-chest CPR, or mechanical CPR with a device (AutoPulse-CPR, Cardio Pump) compared to manual CPR guided with quality CPR device. The results will give the investigators important insights into the haemodynamics of CPR which may guide future strategies for the management of cardiac arrest. The research group is also interested in CPR related injuries and mattress effect. Quality of life after CA is evaluated among survivals and the cause of death among non-survivors.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1000
• Est. completion date: December 2018
• Est. primary completion date: December 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• cardiac arrest

• > 18 years of age

Exclusion Criteria:

• < 18 years of age

Related Conditions & MeSH terms

• Cardiac Arrest
• Heart Arrest

Locations

Country	Name	City	State
Finland	Tampere University Hospital	Tampere	Pirkanmaa
Finland	Department of Anesthesiology and Intensive Care, Turku University Hospital	Turku

Sponsors (3)

Lead Sponsor	Collaborator
Tampere University Hospital	Turku University Hospital, Uppsala University

Country where clinical trial is conducted

Finland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Change in hemodynamics, Change in cerebral saturation, Change in quality of CPR		During resuscitation
Primary	The success rate of current guidelines (depth and frequency of chest compression, epidemiology)		During the resuscitation
Primary	Quality of life after CA	Quality of life after CA is usually fairly good measurement of quality of resuscitation attempt	6 months
Secondary	Invasive arterial pressures, cerebral oxygenation (NIRS), EtCO2		During the resuscitation
Secondary	survival of cardiac arrest		hospital discharge