Hypothermia for Cardiac Arrest in Paediatrics

Status Completed

Clinical Trial Summary

The investigators hypothesized that, following cardiac arrest in pediatric patients, hypothermia therapy will improve the proportion of patients with a good functional outcome compared to a normothermic control group.

Clinical Trial Description

Cardiac arrest is associated with a high morbidity and mortality in children and hypothermia therapy has the potential to be beneficial in children following cardiac arrest. We have a track record of both clinical and laboratory research of hypothermia therapy following cardiac arrest at the Hospital for Sick Children and have completed a 3-site randomized controlled pilot study of hypothermia therapy following cardiac arrest in children funded by The Hospital for Sick Children Research Institute and the Heart and Stroke Foundation of Ontario. This protocol was used to develop the protocol for the THAPCA trials (see 2 manuscripts published Moler et al NEJM 2015 and 2017 and multiple other manuscripts). Hypothermia therapy, compared to active maintenance of normothermia, had no beneficial effect on functional outcome or mortality in children with out-of-hospital or in-hospital cardiac arrest. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00754481
Study type	Interventional
Source	The Hospital for Sick Children
Contact
Status	Completed
Phase	Phase 2
Start date	January 2005
Completion date	September 2010

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06048068` - Removing Surrogates' Uncertainty to Reduce Fear and Anxiety After Cardiac Events	N/A
Recruiting	`NCT05558228` - Accuracy of Doppler Ultrasound Versus Manual Palpation of Pulse in Cardiac Arrest
Completed	`NCT03685383` - Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resuscitation	N/A
Completed	`NCT04584645` - A Digital Flu Intervention for People With Cardiovascular Conditions	N/A
Completed	`NCT04619498` - Effectiveness of an Interactive Cognitive Support Tablet App to Improve the Management of Pediatric Cardiac Arrest	N/A
Not yet recruiting	`NCT05649891` - Checklists Resuscitation Emergency Department	N/A
Withdrawn	`NCT02352350` - Lactate in Cardiac Arrest	N/A
Completed	`NCT03024021` - Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia
Completed	`NCT02247947` - Proteomics to Identify Prognostic Markers After CPR and to Estimate Neurological Outcome
Completed	`NCT02275234` - Care After Resuscitation
Completed	`NCT01944605` - Intestinal Ischemia as a Stimulus for Systemic Inflammatory Response After Cardiac Arrest	N/A
Completed	`NCT01936597` - Prospective Study of 3 Phone Assistance Strategies to Achieve a Continuous Cardiac Massage	N/A
Completed	`NCT01972087` - Simulation Training to Improve 911 Dispatcher Identification of Cardiac Arrest	N/A
Active, not recruiting	`NCT01239420` - Norwegian Cardio-Respiratory Arrest Study
Completed	`NCT01191736` - Ultra-Brief Versus Brief Hands Only CPR Video Training With and Without Psychomotor Skill Practice	N/A
Completed	`NCT00878644` - Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial	Phase 3
Completed	`NCT00880087` - Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial	N/A
Completed	`NCT00729794` - Vasopressin, Epinephrine, and Steroids for Cardiac Arrest	Phase 3
Recruiting	`NCT00441753` - Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest	N/A
Completed	`NCT00347477` - Fluid Shifts in Patients Treated With Therapeutic Hypothermia After Cardiac Arrest	Phase 3