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NCT00441753 Clinical Trial

Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

Cardiac Arrest Clinical Trial

Official title:
Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00441753
Other study ID # KSCH0601
Secondary ID
Status Recruiting
Phase N/A
First received February 28, 2007
Last updated February 5, 2009
Start date September 2006

Study information
Verified date February 2009
Source Radboud University
Contact Cornelia Hoedemaekers, MD PhD
Phone 00.31.24.3617273
Email C.Hoedemaekers@ic.umcn.nl
Is FDA regulated No
Health authority Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
Study type Observational

Clinical Trial Summary

Survivors of a cardiac arrest frequently develop severe postanoxic encephalopathy. Derangements in cerebral blood after return of spontaneous circulation play an important role in the pathogenesis of postanoxic encephalopathy. In the present study we examine the effect of mild therapeutic hypothermia on cerebral blood flow and carbondioxide reactivity in patients after cardiac arrest.

Recruitment information / eligibility
Status Recruiting
Enrollment 10
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 95 Years
Eligibility Inclusion Criteria:

- adult patients

- GCS after return of circulation < 7

- Induced mild hypothermia for 24 hours

- primary rhythm ventricular fibrillation

Exclusion Criteria:

- Thrombolysis

- Cardiogenic shock with expected survival < 24 hrs

- Pregnancy

- No informed consent

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Netherlands Radboud University Nijmegen Medical Centre Nijmegen

Sponsors (1)
Lead Sponsor Collaborator
Radboud University

Country where clinical trial is conducted

Netherlands, 

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