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Biphasic Defibrillation Study: Trial to Compare Fixed Versus Escalating Energy

Cardiac Arrest Clinical Trial

Official title:
A Pilot Randomized Controlled Trial to Compare Fixed Versus Escalating Energy Regimens for Biphasic Waveform Defibrillation

Clinical Trial Summary

This study will compare the effect of constant low-level energy [150 joules] to an escalating energy [200-300-360 joules] regimen of biphasic waveform defibrillation on multiple patient outcomes.

Clinical Trial Description

This pilot, which will enroll 200 subjects, will allow a reasonable estimate of effect size and this will, in turn, allow for the accurate design and planning of a definitive randomized controlled trial. The following outcomes will be evaluated:

1. Important Clinical Outcomes:

- Successful conversion,

- Resuscitation to one hour,

- Survival to hospital discharge,

- Neurological function, and

- Quality of life.

2. Process Outcomes:

- Number of shocks required,

- Recurrences of VF, and

- Responsiveness to varying periods of pulselessness.

3. Adverse Outcomes:

- Myocardial damage. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00212992
Study type Interventional
Source Ottawa Hospital Research Institute
Contact
Status Completed
Phase Phase 3
Start date March 2001
Completion date July 2006
View Details
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