Cardiac Amyloidosis Clinical Trial
Official title:
Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure
Tne aim purpose of this observational, multicentre and propective study is to determine the prevalence of cardiac amyloidosis in geriatric patients aged 80 years and older hospitalized within the last 12 months for heart failure with left ventricular hypertrophy (septum ≥ 12 mm) on echocardiography
Patients recruitment will be curry out in 31 geriatric or cardiologic centres. Patients will be recruited for 24 months. Each patient will participate in the study for 12 months (baseline visit, follow-up phone calls every 3 months up to 12 months i.e., at 3, 6, 9 and 12 months). The following data will be collected at teh baseline visit: Medical history, demography, clinical data, frailty status assessed by Fried, Triage Risk Screening Tool (TRST), triggers for cardiac decompensation, biological examination, genetic testing, echocardiographic data and other data. Bone scanning with 99mTc-DPD or 99mTc-HMDP (early or late time with SPECT will be done during hospitalization or after discharge depending on availability at the imaging centre. The results of each examination will be evaluated to establish the existence and degree of fixation in the myocardium and to determine its distribution. Follow-up phone s will be conducted every 3 months up to 12 months to collect hospitalizations for heart failure, hospitalizations for other cardio-vascular events, hospitalizations for non-cardiac events, admission to nursing homes or long-term care (LTC) facilities and death ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04459169 -
Cardiac Amyloidosis : Diagnostic Using Red Flag Signals
|
||
Recruiting |
NCT03029026 -
The Role of Occult Cardiac Amyloid in the Elderly With Aortic Stenosis.
|
||
Recruiting |
NCT06034405 -
Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis
|
||
Recruiting |
NCT04915235 -
Prevalence and Prognosis of Cardiac Amiloidosis in Turkey
|
||
Recruiting |
NCT02966522 -
Thalidomide/Dexamethasone Treatment And PET Evaluation In Organ Involvemenet of Cardiac Amyloidosis
|
Phase 2 | |
Terminated |
NCT03333551 -
Cardiac Uptake of 18F Florbetapir in Patients Undergoing Chemotherapy
|
Phase 4 | |
Recruiting |
NCT04105634 -
Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients With Light Chain Amyloidosis Using PET/CT
|
Early Phase 1 | |
Recruiting |
NCT05139797 -
Artificial Intelligence Guided Echocardiographic Screening of Rare Diseases (EchoNet-Screening)
|
||
Not yet recruiting |
NCT05593679 -
A Multi-center Cardiac PYP Scan Registry in Taiwan.
|
||
Not yet recruiting |
NCT04146415 -
Diagnosis of Cardiac Amyloidosis With 99mTc-PYP; Comparison Between Planar Imaging, SPECT/CT and Cardiac-dedicated CZT Camera
|
N/A | |
Recruiting |
NCT06469372 -
Cardiac Amyloidosis Discovery Trial
|
N/A | |
Recruiting |
NCT04856267 -
Exploration of Arrhythmia Burden in Cardiac Amyloidosis Using Implantable Loop Recorders
|
||
Completed |
NCT03119558 -
PET/MRI Evaluation of Cardiac Amyloid
|
Early Phase 1 | |
Recruiting |
NCT02798705 -
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis
|
||
Not yet recruiting |
NCT04387344 -
Morpho-functional Cardiac Modifications in Treated Mutated Transthyretin Cardiac Amyloidosis
|
||
Recruiting |
NCT06129656 -
Cardiac Amyloidosis Registry of University Hospital Leipzig
|
||
Terminated |
NCT01683825 -
Imaging Cardiac Amyloidosis: A Pilot Study Using F-18 Florbetapir Positron Emission Tomography
|
Phase 4 | |
Withdrawn |
NCT04363294 -
Targeted Testing for ATTR Among Aortic Stenosis Patients-Pilot
|
N/A | |
Not yet recruiting |
NCT04661800 -
Study of Olfactory Disorders in Patients With Cardiac Amyloidosis
|
N/A | |
Terminated |
NCT03232632 -
Assessment of Cardiac Fixation During PET Using a New Drug Within Amyloid Cardiac Injuries.
|
Early Phase 1 |