Carcinoma Clinical Trial
Official title:
What Benefit of a Full Analysis of Exome? Routine Care Study in Patients With Solid Tumors
The management of cancers and their therapeutic guidance was until shortly mostly based on
histopathological considerations of the tumor. the development of targeted therapies is a
turning point and keeps increase. These molecules target a specific molecular defect in the
tumor making it more effective and more specific treatment. But these treatments are only
effective if the tumor has a specific molecular abnormality that is characterized and known.
These therapeutic progresses have been made possible through the decoding of the human genome
and the molecular defects occurring during the carcinogenesis process. Now, dozens of
therapies targeting a specific molecular abnormality are available in the therapeutic arsenal
and dozens more are under development in clinical trials Phase 1 to 3.
In recent years, the democratization of next generation sequencing has opened a new era in
cancer research but also for molecular diagnostics. Indeed, the enormous sequencing
capabilities offered by high-throughput sequencing technologies allow analysis in a limited
time the entire coding sequence of the genome (exome), or even the entire genome of a tumor
(whole genome sequencing). Thus, the evolution and the development of broadband and
associated bioinformatics tools for genomics techniques now make it possible to establish the
genetic profile of a tumor. Targeted diagnosis of molecular abnormalities and allows to
propose and specifically targeted direct therapeutic identified genetic alterations and
supposedly responsible for tumor development. An analysis of tumor exome by next-generation
sequencing (NGS) and provides information on genetic modifications of these tumors.
This study did not aim to evaluate a therapeutic strategy or treatment. The objective of this
study is to evaluate the clinical benefit of an analysis of exome performed in current
practice at the Centre Georges-François Leclerc from Dijon. The analysis will be performed by
quantifying the number of patients undergoing therapeutic proposal based on the results of
the analysis of the profile of the tumor.
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