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Clinical Trial Summary

Circulating tumor DNA (ctDNA) is a blood-based test that measures dying or dead cancer cells that are already circulating in the blood. In this study, the investigators will enroll patients who are planning to receive surgery to remove their head and neck cancer. The investigators are interested to learn how ctDNA levels change with surgery and over the course of time. The investigators also want to determine if there are certain features of the tumor or the patient themselves that might cause ctDNA to be higher than other patients. Also, the investigators want to explore if the detection of ctDNA following surgery is related to cancer recurrence.


Clinical Trial Description

The investigators will take a piece of the tumor from the surgery and determine if they can identify mutations, or changes in the genetic makeup of the cells due to cancer, that are specific to the tumor. Based on this information, the investigators will design a test using PCR, which is a technology that allows for the amplification of the DNA, that is specific to the mutation identified in the tumor. Once verified, the presence (or absence) of ctDNA in the blood can be measured. The investigators will measure this blood test prior to surgery and at multiple time points following surgery. Specimens will be collected at the time of planned clinical assessments. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04099290
Study type Observational
Source UNC Lineberger Comprehensive Cancer Center
Contact Siddharth Sheth, MD
Phone (919) 966-3856
Email Siddharth.Sheth@unchealth.unc.edu
Status Recruiting
Phase
Start date January 14, 2020
Completion date February 2, 2026

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