Analysis of Melanocytes (Pigment Cells) in Sun-Exposed Skin

Status Completed

Clinical Trial Summary

The purpose of this study is to estimate and define the mean number, degree of confluence, and depth of penetration of melanocytes in chronically sun exposed skin of the head and neck using Mart-1 immunostains on frozen sections. The study was conducted to confirm whether similar results were found using permanent sections. The present study used hematoxaline and eosin (H&E) staining as well as Mart-1 staining, and included patients from both Mayo Clinic Jacksonville and Rochester.

Clinical Trial Description

For each study participant we recorded their age, sex, state they lived in, tumor type, tumor location, recent sun exposure (during the two weeks prior to the surgery), whether or not a follicle was present on the slide, and if so the follicular extension (mm) from the granular layer, presence of atypia, nesting, pagetoid spread. Two slides were obtained; one stained with Mart-1; the other with H&E. For both, melanocyte counts per high power field (400 X HPF magnification) were obtained in three locations of the slide. The mean of the 3 counts was used for analysis, though the individual counts were considered in some data summaries (see below). Classification of photo-aging according to the Glogau scale was noted by the surgeon as type1: "no wrinkles"; type II "wrinkles in motion"; type III "wrinkles at rest" and type IV "only wrinkles." Confluence was categorized by the number of adjacent melanocytes as none, mild (2 side-by-side), moderate (3-6), or severe (7 or more). ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00875381
Study type	Observational
Source	Mayo Clinic
Contact
Status	Completed
Phase	N/A
Start date	September 2007
Completion date	December 2007

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT02743832` - A Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma.	N/A
Active, not recruiting	`NCT02229656` - Olaparib and Radiotherapy in Head and Neck Cancer	Phase 1
Completed	`NCT00389727` - Simultaneous Integrated Boost (SIB)- IMRT	Phase 2
Recruiting	`NCT02328391` - STUDY OBSERVATIONAL OF ERLOTINIB AS SECOND LINE TREATMENT IN PATIENTS WITH SQUAMOUS NSCLC AND EGFR NATIVE	N/A
Completed	`NCT00534950` - Randomized Multicenter Study of 5 vs 6 Weekly Fraction of RT in the Treatment of SCC of the Head and Neck	N/A
Terminated	`NCT00073450` - Study of Lonafarnib in Patients With Recurrent Squamous Cell Carcinoma of the Head and Neck (Study P02530)	Phase 2
Terminated	`NCT01441128` - -02341066 and PF-00299804 for Advanced Non-Small Cell Lung Cancer	Phase 1
Recruiting	`NCT05970497` - A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors	Phase 1
Completed	`NCT01362127` - Neoadjuvant Chemotherapy Versus Radiochemotherapy for Cancer of the Esophagus or Cardia	Phase 2
Completed	`NCT00240682` - Study of Cetuximab in Squamous Cell Carcinoma of the Skin Expressing EGFR	Phase 2
Terminated	`NCT02254044` - Dose Escalation of Bivatuzumab Mertansine in Patients With Advanced Squamous Cell Carcinoma of the Head and Neck or Esophagus	Phase 1
Active, not recruiting	`NCT00829192` - Phase II AK Study in Organ Transplant Patients	Phase 2
Completed	`NCT00539630` - TAX + Cisplatin + 5 F/U vs Cisplatin + 5 F/U in SCCHN	Phase 3
Completed	`NCT00313027` - Cervical Nodal Mets in Squamous Cell Carcinoma of H&N - MRI, FDG-PET, & Histopathologic Correlation	N/A
Recruiting	`NCT04564989` - Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC
Not yet recruiting	`NCT06094829` - Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa
Recruiting	`NCT04481256` - TGF-β And PDL-1 Inhibition in Esophageal Squamous Cell Carcinoma Combined With Chemoradiation TheRapY	N/A
Active, not recruiting	`NCT02664935` - National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer	Phase 2
Terminated	`NCT02438995` - Super-Selective Intraarterial Infusion of Cetuximab (Erbitux) With or Without Radiation Therapy for the Treatment of Unresectable Recurrent Squamous Cell Carcinoma of the Head and Neck	Phase 1
Terminated	`NCT00673049` - Trial Of CP-751, 871 And Erlotinib In Refractory Lung Cancer	Phase 3