A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell

Clinical Trial Summary

This study will compare the efficacy and safety of two doses of belzutifan in participants with advanced renal cell carcinoma (RCC) with clear cell component after prior therapy. The primary hypothesis is that the higher dose of belzutifan is superior to the standard dose in terms of objective response rate (ORR).

See also
Status	Clinical Trial	Phase
Completed	`NCT02248389` - Evaluation of a Laparoscopic High Intensity Focused Ultrasound Probe for the Ablation of Small Renal Masses	Phase 1
Completed	`NCT03900364` - a Prospective Trial Comparing Robot-assisted Partial Nephrectomy Versus Laparoscopic Partial Nephrectomy	N/A
Completed	`NCT00158782` - Study Of Safety And Tolerability Of GW786034 Given With Lapatinib In Cancer Patients	Phase 1
Completed	`NCT03109015` - Alternative Schedule Sunitinib in Metastatic Renal Cell Carcinoma: Cardiopulmonary Exercise Testing	Phase 2
Completed	`NCT00363194` - A Two-way Crossover Study Of The Effect Of Food On The Pharmacokinetics Of Pazopanib In Cancer Patients	Phase 1
Completed	`NCT01012011` - Regulatory Post Marketing Surveillance Study on Nexavar®	N/A
Completed	`NCT00842790` - Impact of Predicting Anti-angiogenic Response in mRCC Using Functional Imaging	N/A
Completed	`NCT00529802` - Exploratory Study Evaluating Fluorodeoxyglucose - Position Emission Tomography as a Predictive Marker for Therapy With RAD001 in Metastatic Renal Cell Cancer	Phase 2
Completed	`NCT00338884` - Safety And Effectiveness Of Daily Dosing With 37.5 mg Sunitinib Malate In Patients With Advanced Kidney Cancer	Phase 2
Completed	`NCT00356460` - Safety and Efficacy Study of GC1008 to Treat Renal Cell Carcinoma or Malignant Melanoma	Phase 1
Completed	`NCT00387764` - Extension Study to VEG105192 to Assess Pazopanib in Patients With Advanced/Metastatic Renal Cell Cancer	Phase 3
Completed	`NCT00095186` - Safety/Efficacy Study of Oral Recombinant Human Lactoferrin in Renal Cell Carcinoma	Phase 2
Completed	`NCT00043368` - PF-3512676 (CPG 7909) Injection For Patients Who Completed An Oncology Study Using PF-3512676 (CPG 7909)	Phase 2
Completed	`NCT00079612` - Study of Nexavar (Sorafenib, BAY 43-9006) in Patients With Advanced Refractory Cancer	Phase 2
Completed	`NCT00516672` - Phase I Study of Pazopanib Alone and In Combination With Lapatinib in Japanese Patients With Solid Tumors	Phase 1
Withdrawn	`NCT05104905` - A Phase I/II Open Label Single Centre Trial to Assess the Safety, Tolerability and Efficacy of Single Dose Neoadjuvant Anti-CLEVER-1 Antibody Bexmarilimab in Localised Renal Cell and Colon Carcinoma	Phase 1/Phase 2
Terminated	`NCT03685591` - PF-06952229 Treatment in Adult Patients With Advanced Solid Tumors	Phase 1
Withdrawn	`NCT03111901` - Low-dose Interleukin-2 and Pembrolizumab in Melanoma and Renal Cell Cancer	Phase 1/Phase 2
Recruiting	`NCT05544929` - A Study of Safety and Efficacy of KFA115 Alone and in Combination With Pembrolizumab in Patients With Select Advanced Cancers	Phase 1
Completed	`NCT02917772` - Tailored ImmunoTherapy Approach With Nivolumab in Subjects With Metastatic or Advanced Renal Cell Carcinoma	Phase 2

NCT number	NCT04489771
Study type	Interventional
Source	Merck Sharp & Dohme LLC
Contact
Status	Active, not recruiting
Phase	Phase 2
Start date	September 13, 2020
Completion date	October 4, 2025

A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms