Carcinoma, Renal Cell Clinical Trial
Official title:
Evaluation of the Safety and Efficacy of Axitinib in Metastatic Renal Cell Carcinoma Patients With Favorable Prognostic Factors
Aim of the FavorAx study is to evaluate preliminary efficacy and safety of Axitinib in metastatic renal cell carcinoma patients with favorable IMDC prognostic factors who had progressed on sunitinib or pazopanib in the first-line setting.
Axitinib is a tyrosine kinase inhibitor of vascular endothelial growth factor receptor,
platelet-derived growth factor receptor-α, and c-kit. The trial of comparative effectiveness
of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS) was an international
randomized Phase III study designed for registration purposes. This trial randomized 723
metastatic renal cell carcinoma patients with any prognostic features to axitinib or
sorafenib in the second-line setting and demonstrated significant clinical benefit of
axitinib.
Aim of present FavorAx study is to evaluate preliminary efficacy and safety of Axitinib in
metastatic renal cell carcinoma patients with favorable IMDC prognostic factors who had
progressed on sunitinib or pazopanib in the first-line setting.
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