Head and Neck Cancer Clinical Trial
Official title:
RADIATION WITH MITOMYCIN C OR PORFIROMYCIN IN THE TREATMENT OF CANCER OF THE HEAD AND NECK AREA
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in
chemotherapy use different ways to stop tumor cells from dividing so they stop growing or
die. It is not yet known whether combining mitomycin or porfiromycin with radiation therapy
is more effective in treating patients with head and neck cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy plus
either mitomycin or porfiromycin in treating patients with head and neck cancer.
OBJECTIVES: I. Compare the efficacy of mitomycin vs. porfiromycin as an adjunct to
radiotherapy for the treatment of epidermoid carcinomas of the head and neck.
OUTLINE: Randomized study. Arm I: Radiotherapy plus Single-Agent Chemotherapy. Irradiation
of involved head and neck sites by external-beam radiotherapy (EBRT) alone (source not
specified), brachytherapy alone (using permanent or removable radiation sources), or both;
plus Mitomycin, MITO, NSC-26980. Arm II: Radiotherapy plus Single-Agent Chemotherapy.
Radiotherapy as in Arm I; plus Porfiromycin, NSC-56410.
PROJECTED ACCRUAL: Approximately 200 patients will be entered over 3-4 years.
;
Primary Purpose: Treatment
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