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Clinical Trial Summary

This is a multicenter, prospective, observational study in which subjects will be treated with lenvatinib combined with TACE in un-resectable HCC patients who had not received systematic treatment or TACE treatment in the past.


Clinical Trial Description

Only 30% of HCC patients received radical resection. Most of the patients are in the advanced stage and can only receive palliative treatment such as TACE or systemic treatment. Lenvatinib is a multi-target receptor tyrosine kinase inhibitor (TKI), which mainly inhibits vascular endothelial growth factor(VEGF) receptor-1, 2, 3; fibroblast growth factors(FGF) receptor-1, 2, 3, 4; platelet derived growth factor receptor(PDGFR)α; RET and KIT and showed significant anti-tumor effect in REFLECT study. The purpose of this study is to explore the efficacy and safety of Lenvatinib and TACE in unresectable HCC patients. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04560751
Study type Observational
Source Zhejiang Cancer Hospital
Contact Guoliang Shao, Professor
Phone 13989898089
Email zenghuiray@163.com
Status Not yet recruiting
Phase
Start date September 30, 2020
Completion date August 31, 2022

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